Protein Info for DvMF_2146 in Desulfovibrio vulgaris Miyazaki F

Annotation: delta-1-pyrroline-5-carboxylate dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1013 transmembrane" amino acids 662 to 685 (24 residues), see Phobius details PF18083: PutA_N" amino acids 6 to 119 (114 residues), 125.4 bits, see alignment E=1.7e-40 PF01619: Pro_dh" amino acids 129 to 442 (314 residues), 311.9 bits, see alignment E=6.9e-97 TIGR01237: putative delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 496 to 996 (501 residues), 665.9 bits, see alignment E=2.2e-204 PF00171: Aldedh" amino acids 531 to 991 (461 residues), 480.1 bits, see alignment E=9.1e-148

Best Hits

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 100% identity to dvm:DvMF_2146)

Predicted SEED Role

"Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88)" in subsystem Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.2.1.88, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DQH0 at UniProt or InterPro

Protein Sequence (1013 amino acids)

>DvMF_2146 delta-1-pyrroline-5-carboxylate dehydrogenase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MEQHLDARIVERGKEFFKSISGEAPSIFNKGFWTGKVMDWAMQNEGFKVQLFRFVDVLPY
LNTSEALTRHIREYFSADGADVPPVLKWGAGAAGFGGAFTGMLMGKFIRSNIEGMARTFI
IGENTKEAIKGLAKLRKEGFAFTVDLLGEATVSEEEADAYRDGYLEVLDAISREHAKWAP
LTDSTGSTTGPDASQDWGHTPKVNVSIKPSALYSQAKPGDVEGSVQGILSRLVPIYRKIV
EMGGFLCIDMEQLKYREMTLELFKRLRTMPEFRDYPHLSIVLQAYLRCTEHDLDELLAWG
RAERLPFGIRLVKGAYWDYETVMAKQNGWEIPVWTRKPESDICYEKLARRILENNDLVYF
ACASHNVRTISTVMETARALNVPAHRYEFQVLYGMAEPVRKGLKNVAGRVRLYCPYGELI
PGMAYLVRRLLENTANESFLRQSFVDGAELERLLENPQATLERELAAAPPPRSTPAAQPG
IDGLPPFVNESMLDLTIPANRAGFVNAIAEVRGKAGGVIPLFIGGKDVTTDDTIASTNPA
KPAEVIARVCQGGKPEVDAAIEAAQKAFPAWRDTSPADRAMFLHRAADIARRRMFELSAW
QVLEVGKQWDQAFHDVGEGIDFLDYYAHEMLRLGTPRRMGRAPGELNHLFYQPKGIAAVI
APWNFPFAIAIGMAAAAIVTGNPVIFKPSSIASRIGYNLTEIFREAGLPEGVFNYVPGRS
SVMGDYLVEHPQVSMICFTGSMEVGLRIQEKAAKVQPGQMQCKRVIAEMGGKNAIIIDDD
ADLDEAVLQVLYSAFGFQGQKCSACSRVIVLDPIYDRFVERLVKAAQAIKIGPSEDPANY
MGPVADASLQKNILEYVKVAEQEGKVLVKRTDIPAEGCYVPLTIVEGIKPHHRIAQEEIF
GPVLAVMRAGNFDEALAIANGTRFALTGGVFSRSPENLTKARREFRVGNLYLNRGSTGAM
VERQPFGGFKMSGVGSKTGGPDYLLQFMDPRCVTENTMRRGFAPIEEDDDWIG