Protein Info for DvMF_2035 in Desulfovibrio vulgaris Miyazaki F

Annotation: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08267: Meth_synt_1
  • amino acids 3 to 325 (323 residues), 322.6 bits, E=3.4e-100
• TIGR01371: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
  • amino acids 6 to 778 (773 residues), 982.6 bits, E=1.1e-299
• PF01717: Meth_synt_2
  • amino acids 452 to 774 (323 residues), 488.7 bits, E=9e-151

Best Hits

Swiss-Prot: 100% identical to METE_DESVM: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K00549, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [EC: 2.1.1.14] (inferred from 100% identity to dvm:DvMF_2035)

Predicted SEED Role

"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)" in subsystem Methionine Biosynthesis (EC 2.1.1.14)

MetaCyc Pathways

• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• aspartate superpathway (20/25 steps found)
• S-adenosyl-L-methionine salvage II (3/3 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (9/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (13/18 steps found)
• L-methionine biosynthesis II (4/6 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (6/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (6/9 steps found)
• seleno-amino acid biosynthesis (plants) (3/5 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (5/8 steps found)
• S-adenosyl-L-methionine salvage I (2/4 steps found)
• L-methionine biosynthesis III (2/4 steps found)
• L-methionine biosynthesis I (2/5 steps found)
• superpathway of seleno-compound metabolism (6/19 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.14

Sequence Analysis Tools

See B8DMM2 at UniProt or InterPro

Protein Sequence (780 amino acids)

>DvMF_2035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MRTHTLGFPRIGGNRELKKAVEDYWKGAATRQQLEDAARAIRLRNWTLQREAGIDVVPVG
DFALYDHILDAALLLGVIPPRFRNDDAPRDIDLMFRMARGQGGDRPVAPLEMTKWFDTNY
HYLVPELDAATTFAPDAAPLLALIDEALAAGFTPKAVLPGPMTFLWLSKRVDGGTRWSLL
PALLDAYGALLRDVAARCPLIQLDEPILSLDLADDIRSRFVPAYARLRVAVPDATLLLAS
YFAPVGDNLPVALSLPVDVVHLDLVRGPEDLTPALDILTRAAARQPADSGLPQSGSQSGI
ALSLGVINGRNVWRVDADKAAAPVRAAVAALGPDRVWVAPSCSLLHCPVDLDAETGLDPE
VAQWLAFARQKCAEVRLVADMCDLNGRADAPETAAALARNRAALAARAASPVIHDPAVAV
RAGTVTPEMGWRATPYTARIAAQRAALRLPVLPATTIGSFPQTVDIRAQRRKLRTGQITE
AQYDAAMREAIATAIREQEALGLDVLVHGEPERNDMVEYFGEQLRGFCITANGWVQSYGT
RCVKPPLLYGDVARPGPMTVRWITHAQSLTQKPVKGMLTGPVTIACWSFVRDDVPRPVVF
RQLALAIRDEVADLEAAGIGVIQIDEPALREGLPLRRAAHAAYLDAAVGAFRLASSGVRD
ATQIHTHMCYCDFHDIIDHVAALDADVISLEASRSRMELLDVFATHAYPNEVGPGVYDIH
SPRVPSIDEMETLLRAASRVLPLDRLWANPDCGLKTRDWPETRASLAHLVAAATRVREGG