Protein Info for DvMF_1971 in Desulfovibrio vulgaris Miyazaki F

Annotation: CRISPR-associated helicase Cas3 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 PF18019: Cas3_HD" amino acids 15 to 140 (126 residues), 24.6 bits, see alignment E=5e-09 TIGR01596: CRISPR-associated endonuclease Cas3-HD" amino acids 18 to 173 (156 residues), 85.6 bits, see alignment E=4.2e-28 PF01966: HD" amino acids 20 to 108 (89 residues), 22.2 bits, see alignment E=2.9e-08 TIGR01587: CRISPR-associated helicase Cas3" amino acids 240 to 588 (349 residues), 117.9 bits, see alignment E=5.5e-38 PF00270: DEAD" amino acids 241 to 412 (172 residues), 35 bits, see alignment E=2.4e-12

Best Hits

KEGG orthology group: K07012, (no description) (inferred from 100% identity to dvm:DvMF_1971)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DQ50 at UniProt or InterPro

Protein Sequence (740 amino acids)

>DvMF_1971 CRISPR-associated helicase Cas3 (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MKYAHTLANRPESDWEPLSRHLEEVADLAAHFASAFGAGEWGLAAGLLHDVGKQSTAFQA
YLRASTAGKGPGRGPDHSTAGAQWAHGHYNAKLGKLLAYALAGHHAGLPDGIESLAPRLK
RAVEPWHSPGDDIAARVPEITGLPLAGRMPSLGFQLMLFVRMVFSCLVDADSLCTEAFTT
PDKAAWRRGYLPLSELKVRLDRHLDHLATHAPATPVNSLRAGILAACRNAAPNVPGLFSL
TVPTGGGKTLSSLAFALDHAQAHGLRRVIYAIPYTSIIEQTARVFREALNDTDDQAVLEH
HSNFVPLRADGTPVTPRREGQDDDAGEGRRSVLAAENWDAPVVVTTNVQFLESLFAARRS
PCRKLHNIARSVVILDEAQMLPPEHLLPCLEALRALVLDYGCSVVLCTATQPALGKREGF
DRGLEQVREITPNPEQLATALRRVEVTDAGTLDDAQLAARLAGQPQVLCVVNTRPHARAL
YELLAPQGDAVHLSAAMCPAHRTEVLRGVRQRLLQGQPCRVVATQLVEAGVDIDFPVVYR
AMAGVDSLAQAAGRCNREGNLERGQVYLFTPQDSPPPFVRQAAQAARTALRRNPDPLALD
TVEAYFRELYWQKGDRLDSANLLPLMRDSAPRLDFPFPEVAHLFRLIPDDTIPLLIPYDD
DARALIAELPYTPAPARLLRRAQRYTVGVYPRVLAALVQAGAAHLATEECAVLINEDLYD
DRLGLCADNPTYRNPESLLG