Protein Info for DvMF_1894 in Desulfovibrio vulgaris Miyazaki F

Annotation: N-acylneuraminate-9-phosphate synthase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03102: NeuB
  • amino acids 42 to 273 (232 residues), 233.3 bits, E=2.9e-73
• PF08666: SAF
  • amino acids 296 to 354 (59 residues), 63.2 bits, E=2.6e-21

Best Hits

KEGG orthology group: K01654, N-acetylneuraminate synthase [EC: 2.5.1.56] (inferred from 100% identity to dvm:DvMF_1894)

Predicted SEED Role

"N-acetylneuraminate synthase (EC 2.5.1.56)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 2.5.1.56)

MetaCyc Pathways

• CMP-N-acetylneuraminate biosynthesis II (bacteria) (3/3 steps found)
• superpathway of CMP-sialic acids biosynthesis (3/15 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.56

Use Curated BLAST to search for 2.5.1.56

Sequence Analysis Tools

See B8DMJ3 at UniProt or InterPro

Protein Sequence (354 amino acids)

>DvMF_1894 N-acylneuraminate-9-phosphate synthase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MRLTEIFSSRPACARSAGIQRPYIIAEAGVNHEGSMDIARRLVDEACAGGAHAIKFQTYK
AATLASKDSPAYWDTTKEPTSSQYELFTRHDKFWKGEFEALKKHCDSAGIEFMSTPFDVE
SARFLNDMMDVYKISSSDITNKPFIEFMCGFGKPIILSTGAAHLHEIAEAVEWIEAKGNP
LALLHCVLNYPTDDVNAALGMIPALRQHFPQHVIGYSDHTLPRDMKVLEVATLLGARILE
KHFTHDKTLPGNDHYHAMDKDDLARFNASLDRILPMVGPFTISALESEAPARRNARRSLV
AARPIAAGAVITRDDLTWKRPAHGVSPREIDAVLGKRARADIAEDTVLQWSHLE