Protein Info for DvMF_1604 in Desulfovibrio vulgaris Miyazaki F

Annotation: proton-translocating NADH-quinone oxidoreductase, chain M (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 519 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 34 to 53 (20 residues), see Phobius details amino acids 80 to 104 (25 residues), see Phobius details amino acids 111 to 128 (18 residues), see Phobius details amino acids 134 to 152 (19 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 205 to 225 (21 residues), see Phobius details amino acids 236 to 256 (21 residues), see Phobius details amino acids 268 to 291 (24 residues), see Phobius details amino acids 298 to 317 (20 residues), see Phobius details amino acids 329 to 347 (19 residues), see Phobius details amino acids 365 to 384 (20 residues), see Phobius details amino acids 402 to 424 (23 residues), see Phobius details amino acids 446 to 467 (22 residues), see Phobius details TIGR01972: proton-translocating NADH-quinone oxidoreductase, chain M" amino acids 8 to 479 (472 residues), 559.4 bits, see alignment E=3.5e-172 PF00361: Proton_antipo_M" amino acids 128 to 412 (285 residues), 253.5 bits, see alignment E=1.3e-79

Best Hits

Swiss-Prot: 42% identical to NU4M_MARPO: NADH-ubiquinone oxidoreductase chain 4 (ND4) from Marchantia polymorpha

KEGG orthology group: K00342, NADH dehydrogenase I subunit M [EC: 1.6.5.3] (inferred from 100% identity to dvm:DvMF_1604)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain M (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DS13 at UniProt or InterPro

Protein Sequence (519 amino acids)

>DvMF_1604 proton-translocating NADH-quinone oxidoreductase, chain M (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MYPDIPVLSILIFLPLVAAALLLPLRDDETVRRVSLAASLVGLAAGWPLIAFNPDAGFQF
VERMTWVARWGLEYHLAVDGISILMVWLTLFTLPLCVLCSWTYIGKRVKEFHICLLLMTS
ACIGVFTSMDLVLFYVFWEAMLIPMYLLIAVWGGAERRYASIKFFLYTLAGSTLLLVAIV
AFRIAGGTFSIPDLMQQTFGFRFQYWAFLAMALAFAIKVPMFPFHTWLPAAHVQAPSAGS
VILAAVLLKMGTYGFLRFCLPLTPEASVHFAPLMIGVSVVSILYGGAVALGQTDIKKLVA
YSSVAHMGFVTLGIFLFQKSGVQGALLQMLNHGIVTGALFMMIGAMYERSHSREVADNMG
MGKYLPAFMFFWGLYALASFGFPGTNGFVGEVLVFVAAFQQSLTVGALIVPGALLAAAYM
FRVSLRMAWGSPSTAKTWNDLNRREWAYLLLPAVLVLWIGLAPAPFLRLIDPSIDRLLAD
LRGRAPVKEAPLALNHADAVRHEPPAILASAPIAKEVRQ