Protein Info for DvMF_1530 in Desulfovibrio vulgaris Miyazaki F

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 896 PF08448: PAS_4" amino acids 61 to 163 (103 residues), 45 bits, see alignment E=4.5e-15 amino acids 189 to 243 (55 residues), 23.3 bits, see alignment 2.6e-08 amino acids 344 to 448 (105 residues), 39.8 bits, see alignment E=1.9e-13 TIGR00229: PAS domain S-box protein" amino acids 179 to 241 (63 residues), 38.1 bits, see alignment 1.5e-13 amino acids 331 to 452 (122 residues), 76.5 bits, see alignment E=2e-25 PF13188: PAS_8" amino acids 183 to 237 (55 residues), 40.3 bits, see alignment 8.2e-14 amino acids 334 to 381 (48 residues), 30 bits, see alignment 1.5e-10 PF00989: PAS" amino acids 184 to 236 (53 residues), 33.1 bits, see alignment 2e-11 amino acids 335 to 444 (110 residues), 51.6 bits, see alignment E=3.7e-17 PF13426: PAS_9" amino acids 344 to 446 (103 residues), 62.1 bits, see alignment E=2.1e-20 PF08447: PAS_3" amino acids 356 to 440 (85 residues), 26 bits, see alignment E=3.6e-09 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 454 to 618 (165 residues), 143 bits, see alignment E=7.1e-46 PF00990: GGDEF" amino acids 458 to 614 (157 residues), 170.8 bits, see alignment E=8.5e-54 PF00563: EAL" amino acids 636 to 870 (235 residues), 233 bits, see alignment E=1.3e-72

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_1530)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DLV2 at UniProt or InterPro

Protein Sequence (896 amino acids)

>DvMF_1530 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTGDMPQHMRDEEQEHRAAGGPANAENPGQNAPGQGAPGQNTSGSQTPGLLRALLDNPLV
ALFLRDGEGRYLAANHLYADLAGVPGKDVVGLSPRDIFPHAVASALLDEDRRVAEDSTPL
LCERMLPADEAERVFRVAKLPLPPEVAGPGAVLGLAFDVTALVEAEIEEEVRQRTAALAE
STARFRALFELAPDAVYVRGEGGRIVDCNRAAERMSGHPRETLLSLRTADLLPPDIEVRI
DNLLTGCPLPVATHPDSTPAEPRQGTDGANPGSGFCPTGGFCMEGICTAAHGPHEAEVSV
EPLPLSLLRGKGMTALVVVHDISGRRTAERQARLFERVFRNALEGICITDPEGIIVAVNP
AFTTITGYPADDAVGQSPRLLKSHHHDSAFYEDMWRALVEEGRWEDEIWNRRRNGEVYPE
WLSISAIPGPTGRTEYYVAVFHDITELKAKESQIQHQAHHDALTGLPNRALLRDRLGMAI
NGARREDRKVAVLSVDLDNFKQVNDSLGHMVGDIYLQQAAEQMRQMVRPQDTLARVGGDE
FVVVLQDVEGERDAAQVAERLLARFTDPVRVQEHELFVGASVGIALFPDDGDDPDTLVRN
ADIAMSRAKEQGKRRYHLFTPAMNDRAVRRLSLEGDLHRALAAGDITAHYQPRVDLNTGL
ITGMEALARWIRADGSQEHPAEFIPLAESTGLIVPLGEHMLRLACAKTRALCDAGHADLH
VAVNLSVHQFRHRNLVGMVADVLAETGLPPHLLELEITESTIVTDVDHTIRKLNQLAEMG
IALSVDDFGTGYSSLYQLKNLPLTSLKIDRSFIRDIPDDPNDAAIAATIITMADRLGLRV
VAEGVETPEQLNFLLLEGCHEVQGFLFSRPLPPDEFTALLARGRLLTVPRDGDGGI