Protein Info for DvMF_0617 in Desulfovibrio vulgaris Miyazaki F

Annotation: diguanylate cyclase/phosphodiesterase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 883 PF00563: EAL" amino acids 305 to 531 (227 residues), 176.7 bits, see alignment E=8.1e-56 PF00571: CBS" amino acids 564 to 615 (52 residues), 21.1 bits, see alignment 5e-08 amino acids 631 to 689 (59 residues), 19.3 bits, see alignment 1.8e-07 PF00990: GGDEF" amino acids 701 to 798 (98 residues), 58.7 bits, see alignment E=9.5e-20 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 701 to 798 (98 residues), 56.2 bits, see alignment E=1.7e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_0617)

Predicted SEED Role

"EAL domain/GGDEF domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DJX8 at UniProt or InterPro

Protein Sequence (883 amino acids)

>DvMF_0617 diguanylate cyclase/phosphodiesterase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MLTTRRETYWRRTASRNRHHAFKSKRTADGTLTIPRRIMPDNVSDSIRGGCMQHTWLEPF
LEILGRRRGDTGHAAHPGDLAPGAGHAEDMPPVFSTIEVPEAVPGPTPGAASATLSAATP
GARATSRTVPDSAHHAHAAHATDASVREMVARHEALHMLLVRMVDHVLVRDLYGEEITAG
IESLLVDGLWAALPGLSGQPASGHHLLPLESGEFLVFWPEPAARPQRLADAAFTMKLKLQ
HHLKDSVLRWTGREVSIGVGCATYRRRPGAEPRREFFQAVREARTMARKELDLSDLRLAR
DFKAVLQDNAIRTLYQPIVRFPTGRIMAWEALSRGPVDTPFHSPMMLFDIAEELGMLFAL
ERICRERAIACAGTLAPDQKLFLNIHPRTLTDPGFTPGSTLEAVRAMGLAPENIVFEITE
RHSIRDFGVFYKTLSHYRGQGFKVAIDDAGTGYSGLATIAELKPDFIKIDMSLIRNINRD
PVRRALMETLVSFAEKIGSRVIAEGIETREEAATLMAIGAHYGQGYYLGRPDHPKQETHV
DIGELRPTAQLPSVGSLACSMPVGELAEPAHTVPPTTLAGEVRRLFETSDPLTSIAVTDE
RGKPLGLIMDYHLNRQLSAQYGVALYFKRPVSAVMDARPLVLEQTTPVEDAARLAMSRSR
LQAYDDIMITRAGVLAGTVSVQRLLHKLAEVQVELAKGTNPLTGLPGNVALEKELETRLA
GGQPFSLLYADLDNFKSYNDTYGFKNGDRIILLLAKVLSWAVQRHGAKGDYVAHIGGDDF
VCITSPRHAERVCRAATRCFGRLVRGCYCAEDIARGWITARGRDGMERRFPFVSVSLAVL
DCHERSNLHEIGERAAHVKHLAKAIPGNAYVLECGVCQMRALH