Protein Info for DvMF_0215 in Desulfovibrio vulgaris Miyazaki F

Annotation: two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 528 transmembrane" amino acids 73 to 92 (20 residues), see Phobius details PF00072: Response_reg" amino acids 5 to 113 (109 residues), 101.6 bits, see alignment E=9e-33 PF00158: Sigma54_activat" amino acids 142 to 308 (167 residues), 232.3 bits, see alignment E=8.3e-73 PF14532: Sigma54_activ_2" amino acids 143 to 313 (171 residues), 69.1 bits, see alignment E=1.5e-22 PF07728: AAA_5" amino acids 166 to 284 (119 residues), 31.5 bits, see alignment E=4.8e-11 PF02954: HTH_8" amino acids 481 to 521 (41 residues), 53.2 bits, see alignment 5.8e-18

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_0215)

Predicted SEED Role

"Response regulator of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DNW7 at UniProt or InterPro

Protein Sequence (528 amino acids)

>DvMF_0215 two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MKRLLVIDDEPGHRLMVRAVMEDSGWSVEEAGSGEEGLEHLAQDRVNVVLLDMRMPGMDG
QETLARIQEMYPGLPVVMLTAFGTVGSAVVAMKKGAFDYLTKPADNEELTAVLEKAWDFG
RLLEENENLRRRLSDDDPTAPIVGASQAMCRVRDFIRQAGPSEATILIMGESGTGKELIA
QGLHDASNRADQPLVKVNCAALPGHLLESELFGYMKGAFTGAVRDKPGRFQLARGGTLFL
DEIGELPLELQSKLLRALQERVVEPLGAVRPVPVDVRIIAATNRDLKRAVEAGEFREDLF
FRLNVLEVISPPLRDRLEDLPMLAGRLLERLCRKNKKGIRSVSPEFLDALMRYSWPGNVR
ELENVLERALILSRSDTLGPDSLPSQVLADRADRWERGGPDGGQYRGQDRVGDRQRPYSS
DRPDMSDRAGMVDRAFERQGRPWGQDAASAIPRGDASWSGEGDGFMPGGYGGAPGAYPGS
LDDAERDALLRALEVHGGHRERTADALGISRRTLQYKLKKFGLIRRGM