Protein Info for DvMF_0213 in Desulfovibrio vulgaris Miyazaki F

Annotation: multi-sensor signal transduction histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 722 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 243 to 265 (23 residues), see Phobius details PF08448: PAS_4" amino acids 285 to 382 (98 residues), 28.2 bits, see alignment E=3e-10 PF00512: HisKA" amino acids 399 to 461 (63 residues), 54 bits, see alignment E=2.1e-18 PF02518: HATPase_c" amino acids 504 to 614 (111 residues), 84.7 bits, see alignment E=9.3e-28

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_0213)

Predicted SEED Role

"Sensor protein of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DNW6 at UniProt or InterPro

Protein Sequence (722 amino acids)

>DvMF_0213 multi-sensor signal transduction histidine kinase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MDIADKNTERSTLIIAVMALVTIGLSLIVSTGQTLNRQEEAGTQHLILTARSVLQAVETS
LRRGLFMRPNGPGLFSPGTAELFRELEQSGDVLFVGIIDRQGGRVLTSRPTQEAGGTLVF
PPEALQDLAQKGEWHGRATFGKLSAYVYGKRILPRSHTLMHDTDLDDTGQVRPEAGADGG
QAHGPGPSGPSGPSGPSGSSGPPGSFGQGDFASDDPNQLPTFLVVGLDMAKHLAVYRGFR
QNALFQAAYILAAAVFIWVLTMSFLKRREQAGRAAVLERFQARLVDNLPDGLLTITQDNV
VRAANPAAHDIMKARDGSLAGMDVADLPPEVAGCIAGPDSGATPGWANRTVDGAHLEILT
LPIRESDEEHDRLVIIRDRTQIRELEKSLSEAEKLAAVGTLAAGVAHEIRNPLSALRGFA
QYFAKKLAGKQPDENYAQTMVREADRLNRVITDLLYLARPRAIEPREVSLGQLAAELESL
VRFDAGKLGVHMRTSLGPDLVMADEDALKQALLNLVLNSLDALAQCPQPAAGVGREIHIS
SMASDGGVWVFVRDTGPGMSREQREQAFEPFYTTKKKGTGLGLALVHKTMRDHGGRAQID
SEVGRGTTVALFFPGAGHAARTGQAERAGGMNVPEGGDPLDHGADMPTGNCPGAAAFDMA
TANREGRGEGHGGIAPGGDAGNATGHERAAAGHGAPGHAASGHSTTDPSATDTVIDITED
KR