Protein Info for DvMF_0211 in Desulfovibrio vulgaris Miyazaki F

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1076 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 145 to 163 (19 residues), see Phobius details amino acids 183 to 202 (20 residues), see Phobius details PF17203: sCache_3_2" amino acids 37 to 173 (137 residues), 39.4 bits, see alignment E=2.9e-13 PF00672: HAMP" amino acids 199 to 250 (52 residues), 32 bits, see alignment 5.9e-11 TIGR00229: PAS domain S-box protein" amino acids 417 to 463 (47 residues), 24.5 bits, see alignment (E = 2.4e-09) amino acids 504 to 630 (127 residues), 60.4 bits, see alignment E=1.9e-20 PF13188: PAS_8" amino acids 507 to 563 (57 residues), 31.7 bits, see alignment 4.9e-11 PF00989: PAS" amino acids 508 to 620 (113 residues), 25.9 bits, see alignment E=3.9e-09 PF13426: PAS_9" amino acids 518 to 621 (104 residues), 39.7 bits, see alignment E=2.3e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 630 to 795 (166 residues), 155 bits, see alignment E=1.4e-49 PF00990: GGDEF" amino acids 634 to 791 (158 residues), 169.3 bits, see alignment E=2.7e-53 PF00563: EAL" amino acids 813 to 1048 (236 residues), 260.1 bits, see alignment E=7.8e-81

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_0211)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DNW4 at UniProt or InterPro

Protein Sequence (1076 amino acids)

>DvMF_0211 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MRRSRLFGRTLRGLIVLFGVYAAVTSIYSGWTLHTLLIREYESKALAIARAIAGADLESL
IGRDVTTVQSRIDQFLGIDGVSYVLVADGRGETVAHTFVPVVPEPVRELVASLAGVRMNE
VTVLRDRLSLPRPQGGASGGGGREVMHVTMPVFAGVGGFVHIGMDRGRISDYIDGAILRQ
QGLGLAFFAACAVGAWMLLYSISRPLMRLTDQARRVAVHDFSAPPDLPAMKADDEIGDLS
RAMHTMSRDLAGLVEGLEDSVRQATAELGGALEQLSTIVAGMADGLLVTDPQGLVLRSNA
ALCEMFGLDADPDGRSVCEVFGFVAPAVRMVGDGIHEFAFETEDGEDIVPEAVVRDNAAL
LAFLDGADVPGQPMTGVSCTLPGPSGALAARPVTGPDQGLPQGAPCPSGTGTALRSGEVA
AVRRDGTPCWVELSLVRRQVMGTTYGICLVRDVTERRRAQEALHRAHGMLERKVRERTRE
LSRANAQLMLENAERRTVEQALRRAEARFRGIFEHALEGIFQSTPEGRFLSVNPAMARIL
GYEGVQELLEGVESIGDGVYADPARRDEFVARMEEHGQVNAFEFRGRRKGGDLIWLSVNA
RRVPGADGATMYYEGFLEDVTMGHESRERLEHQAFHDPLTGLPNRVLFHDRLQMALKRAA
RRRNYTFAMLYLDLDRFKVINDSLGHDVGDALLKVVSAKLRECVRDVDTVARFGGDEFGV
LLEETPTRGTAVRVARRIRAHLAEPVRIGPHEVFTTASIGIVLRTDQYSTPEELVRDADT
AMYRAKEQGQSRFKVFNKRMREEALRLLTIETDLRRAVERQEMRLHYQPVVALEDGGLHG
VEALLRWTRTEGGDISPAEFVPVAEDTGLITSIGAFALEEVCLQLRRWNEAGLPPPGVVH
VNISGRQFMQPGLPHAVEMLLERTGTDPRSLRFEVTESVLMRHGSQAITVMAQLRDLGIR
LCLDDFGTGYSSLGYLKRLPVDSIKIDRSFVAGLEHDRDGQAIVRSIVSLGLHLGLEIVA
EGVETPTQAEMLASLGCRYAQGFLYAPPVSADDLAAMLDATPFPSTGGGVFVGGSV