Protein Info for Shewana3_3790 in Shewanella sp. ANA-3

Annotation: HsdR family type I site-specific deoxyribonuclease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1053 PF04313: HSDR_N" amino acids 4 to 215 (212 residues), 145.5 bits, see alignment E=3.8e-46 TIGR00348: type I site-specific deoxyribonuclease, HsdR family" amino acids 8 to 742 (735 residues), 542.4 bits, see alignment E=8.7e-167 PF04851: ResIII" amino acids 316 to 487 (172 residues), 74.4 bits, see alignment E=2.1e-24 PF18766: SWI2_SNF2" amino acids 320 to 551 (232 residues), 252.2 bits, see alignment E=9.5e-79 PF11867: T1RH-like_C" amino acids 781 to 1023 (243 residues), 58 bits, see alignment E=2.1e-19

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 100% identity to shn:Shewana3_3790)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L1T9 at UniProt or InterPro

Protein Sequence (1053 amino acids)

>Shewana3_3790 HsdR family type I site-specific deoxyribonuclease (RefSeq) (Shewanella sp. ANA-3)
MSNNEFDKVEQPAIAQLHQLGWHYIPGKALAPEHSNQERDYLRDVVLVKRLTQAIERINP
WISEENLRKVVRMVTHPQCAGLMEYNHGFYQTMVGYLSVEQDLGKGKKGQTVKLIDFDDV
SNNEFICTNQFKVEGTKQTIIPDIVCFVNGLPLAVIECKSPFISTPVVCGIDQLRRYANQ
RHPEDFEGAEKLFWYNQLMVSTSRDIARVGTISSPAQYYADWKDAYPLTDAQIAQVDSDN
VVPLAKKLTVEQPVASVDAAGSELPQVAEPPADYQVAKVTAQQRLLAGMFSRENFLDIVR
NFILFEPDDGRLIKKVARYQQFRAVNKVIHQLKTGKTRKDKSGVVWHTQGSGKSLTMVML
AVKMRHDLELKQYKLVFVTDRTQLDEQLSATFQGAQGETVYNADSVAALRDLLKKDSSDL
VTAMVQKFQDAEKEAQQQGDKSFVNINTSDKIIVLADEAHRTQFGGLATTINAALPNAPK
IGFTGTPLLKTQKMDTAFGGYIDKYKINEAVEDGATVRLLYEGREVKTAVAGESLDALFE
EYFGDYTKEEQQEIKRKYGVEKAVREAPARIRWVCIDLLKHYRERIRPDGFKAMIVVGSR
HAATLFKKTLDELKAPPSEVIISGDHNDPQYIAQYTDKVHQKKVIANFKKPFGIDSPGTD
EKQRKFDNTAFLIVKDMLLTGFDAPIAQVMYIDRKLQDHTLMQAIARVNRNYKGKECGYV
VDYYGLTSYLTDALELFSSDDVEGTYQSLKDELPKLQAAHTRLKAFFKGVTSDDVDDYVV
VLKDDAFRAQFEVAYKRFAKQLNVILPDASAKPYIPDMTFFGKVHHAARNRYRDDGMDLL
DVGEKVRQLVDEHILSTGVDPKIPPVDLLAANFKEHVQKIKSPESKASEIESALKHHINI
NLEDDPEYYRSLSLRLRDIIEKTAGNWERQLELLLEMTNDLSTAHKQAAQNVGLSETEFA
FYNILLAEVTRIHDGDMIDEALHEQIKSTTQALVQVLDEATRIVDFFNKEDEIKRMKKKI
KRVILDQPFGDKALVATLQDRFVELAKHKFGNK