Protein Info for Shewana3_3641 in Shewanella sp. ANA-3

Annotation: microcin-processing peptidase 2 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 PF01523: PmbA_TldD_1st" amino acids 52 to 115 (64 residues), 58.3 bits, see alignment E=1e-19 PF19290: PmbA_TldD_2nd" amino acids 141 to 254 (114 residues), 73.3 bits, see alignment E=3.1e-24 PF19289: PmbA_TldD_3rd" amino acids 262 to 495 (234 residues), 236.8 bits, see alignment E=2.5e-74

Best Hits

Swiss-Prot: 66% identical to TLDD_ECOL6: Metalloprotease TldD (tldD) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03568, TldD protein (inferred from 99% identity to shm:Shewmr7_0486)

MetaCyc: 66% identical to metalloprotease subunit TldD (Escherichia coli)
3.4.24.-

Predicted SEED Role

"TldD protein, part of TldE/TldD proteolytic complex"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L1E2 at UniProt or InterPro

Protein Sequence (497 amino acids)

>Shewana3_3641 microcin-processing peptidase 2 (RefSeq) (Shewanella sp. ANA-3)
MSELPILAKLSERTAMPFLAQVEQSLLKGGLALDGLQSYLNTIHQHKVDFSDLYFQGSRH
ESWVLEDGIIKDGSFHIERGVGVRAISGEKTGFAYADDITPAALSAAAEAARGIAGAGEQ
AKVQAFKRQQALVLYDSLDPIAAMEEVKKINLLKEADAYIRSLDSRIIQVVISLAGVHEE
ILVAASDGTLAADIRPLVRFNCSVILEENGKRERGSAGGGGRHDYSVFMVTDETGLPMCF
AFAREAVRQAQVNLNAIDAPAGEMPVVLGNGWPGVLLHEAVGHGLEGDFNRKGSSAFSGM
VGEQVASKLVTVVDDGTLANRRGSLSIDDEGVQTQRTVLIEDGILKGYMQDKLNARLMGV
APTGNGRRESYAHLPMPRMTNTYMTAGESDPSEIIKSVKKGIYAPNFGGGQVDITSGKFV
FSASEAYLIENGEVTQAIKGATLIGNGPEAMSQISMVGNDMALDKGVGVCGKDGQSVPVG
VGQPTLKLDRLTVGGTA