Protein Info for Shewana3_3602 in Shewanella sp. ANA-3
Annotation: hydratase/decarboxylase family protein (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
KEGG orthology group: K01726, [EC: 4.2.1.-] (inferred from 100% identity to shn:Shewana3_3602)Predicted SEED Role
"2-keto-4-pentenoate hydratase (EC 4.2.1.80)" (EC 4.2.1.80)
MetaCyc Pathways
- 2-hydroxypenta-2,4-dienoate degradation (2/3 steps found)
- catechol degradation I (meta-cleavage pathway) (2/5 steps found)
- catechol degradation II (meta-cleavage pathway) (2/7 steps found)
- toluene degradation I (aerobic) (via o-cresol) (2/7 steps found)
- toluene degradation V (aerobic) (via toluene-cis-diol) (2/7 steps found)
- toluene degradation II (aerobic) (via 4-methylcatechol) (1/6 steps found)
- 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (2/8 steps found)
- p-cumate degradation (2/8 steps found)
- meta cleavage pathway of aromatic compounds (2/10 steps found)
- 4-chloronitrobenzene degradation (1/9 steps found)
- L-tryptophan degradation IX (3/12 steps found)
- L-tryptophan degradation XII (Geobacillus) (3/12 steps found)
- p-cymene degradation (2/11 steps found)
- naphthalene degradation to acetyl-CoA (2/12 steps found)
- toluene degradation IV (aerobic) (via catechol) (2/13 steps found)
- mandelate degradation to acetyl-CoA (3/18 steps found)
- superpathway of aerobic toluene degradation (4/30 steps found)
- superpathway of aromatic compound degradation via 3-oxoadipate (6/35 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (5/42 steps found)
KEGG Metabolic Maps
- 1,4-Dichlorobenzene degradation
- 1- and 2-Methylnaphthalene degradation
- Benzoate degradation via CoA ligation
- Benzoate degradation via hydroxylation
- Biosynthesis of type II polyketide backbone
- Biosynthesis of unsaturated fatty acids
- Biphenyl degradation
- Butanoate metabolism
- Carbazole degradation
- Ethylbenzene degradation
- Fatty acid biosynthesis
- Fluorene degradation
- Limonene and pinene degradation
- Nucleotide sugars metabolism
- Phenylalanine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Porphyrin and chlorophyll metabolism
- Styrene degradation
- Toluene and xylene degradation
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.-, 4.2.1.80
Use Curated BLAST to search for 4.2.1.- or 4.2.1.80
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0L1A5 at UniProt or InterPro
Protein Sequence (271 amino acids)
>Shewana3_3602 hydratase/decarboxylase family protein (RefSeq) (Shewanella sp. ANA-3) MSQTDAKTQLESINAAAQELAQRRAKGEADALLQEALRPKDFPHAFAIQQAIAQLFSAQG NPIAGWKCLLPTAEKTVVAPIYQHDVYIETAECPLYPSSKGLARVEPELAFEIGSDLPPR STPYSGAEIDAALGKTRLALELIKSRYQNPSEANHFDALADGLVNQGLWLGPELLTPAEI ETGHFALSVEIAASGQQASETLQKAAVHPNGFPKAGLYWLVNFLSTQGIGLTRGQYVITG SYAGVLDLPLNQHCQLHYGDLGQFALQFVAK