Protein Info for Shewana3_3588 in Shewanella sp. ANA-3

Annotation: peptidase M16 domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 943 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF00675: Peptidase_M16" amino acids 58 to 195 (138 residues), 87.6 bits, see alignment E=8.3e-29 PF05193: Peptidase_M16_C" amino acids 217 to 398 (182 residues), 62.7 bits, see alignment E=4.4e-21 amino acids 710 to 869 (160 residues), 51.5 bits, see alignment E=1.2e-17

Best Hits

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 100% identity to shn:Shewana3_3588)

Predicted SEED Role

"Peptidase, M16 family"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L191 at UniProt or InterPro

Protein Sequence (943 amino acids)

>Shewana3_3588 peptidase M16 domain-containing protein (RefSeq) (Shewanella sp. ANA-3)
MNNFKRIQFKHLWLWLLFISVAFPLRAVEAPLWPESADLPLSPRVHTGTLANGLHYLLVN
NKTPEQAVIVRMRVDVGSVMETDAEQGLVHFLEHMAFNGSTGLAAEEMIPTLQRLGLSFG
ADTNAVTEFQQTVYQFNLPSNSQDKVDTALFLMREIASNLLLDPTLIEREKAVVLSELRE
RSSADLENYRHQLTFLMPQTLLSQRFPVGEATSIQNANRDKLLSLYQRFYTPSRTSLIVV
GDIDVGRIEHKIKQQFTDWQAAPQAAGVKAQSIGTVQAKTAVEAAAFFDPSLQTSVSLGL
LKPQTPKPDTIALREQEILLELAHGILYRRLESQLLHSQGLYGVSLQIGPQYDIAYGTQM
TLGTQENNWQQGLALLEQTLRQALEFGFSQQEIDQQLKRMHKGYQLSAAGSNTIHSVNIA
ESLVNTVASRRMPVEPAWQLALFEKLMPSITPQKLQQSFKQAWEGTPYLYLTNSKPIENV
EKQLLAAYGASRKQAVKAPETKSIAEFAYSQFGEPGQIVADQRDATTGIRKLEFANGVRL
NVKPTPFNQGMTLVSLNIGFGEVPFPELDGLSYLFNSAFVQGGLGLHDWDSLQDIFAGQD
ISVGLSLREQSFGGEISTNAAELRTQLGVLTAYLVDPGMDQQAEQLFREQVIAEQQSIHS
NPQLEFSNQFARIAHNGDKRYGYGNPDEILKRQFAELAPSFHSAVQQGVIELAIVGDFDE
NKAIAEVAQTLGAIARQPIPKGQTIVPVFPKVPAQMNLTHYGQVDMAALAQVWPTTDMSN
PRELVGLGLLEQVLNILLTENVREKAGASYSPSAFSYSDLNPTGYGYLGLFSVTTKPMLP
EVAKYYAAAVKQVKAPSGISEDLLNRARQPVLEWMHMAPQSNNFWLDLASTAQSQPERFA
GFNQRLALVQQITPAELSQLAQKYLKDDKRLTIETLPAPITAQ