Protein Info for Shewana3_3275 in Shewanella sp. ANA-3

Annotation: cobyric acid synthase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 PF13500: AAA_26" amino acids 34 to 265 (232 residues), 61.3 bits, see alignment E=1.8e-20 PF01656: CbiA" amino acids 35 to 266 (232 residues), 83.9 bits, see alignment E=1.4e-27 TIGR00313: cobyric acid synthase CobQ" amino acids 35 to 534 (500 residues), 469.7 bits, see alignment E=5.8e-145 PF07685: GATase_3" amino acids 286 to 492 (207 residues), 187.7 bits, see alignment E=2.7e-59

Best Hits

Swiss-Prot: 89% identical to COBQ_SHEON: Cobyric acid synthase (cobQ) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to shn:Shewana3_3275)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L0D0 at UniProt or InterPro

Protein Sequence (541 amino acids)

>Shewana3_3275 cobyric acid synthase (RefSeq) (Shewanella sp. ANA-3)
MNSNNASNPTSALSQNLFQGVVSQSEAQHSGAKVLMVQGTTSDAGKSTLVAGICRLLARE
GVKVAPFKPQNMALNSAVTIDGGEIGRAQALQAAACFLAPHTDFNPILLKPSSDTGAQII
VHGKALTTLEASAFFGEKSKDYKAMALNAVLESFARLGQQYQTIVVEGAGSPAEINLREG
DIANMGFAEAVDCPVIIIADIDKGGVFAHLVGTLALLSPSEQARVKGFVINRFRGDISLL
QSGLDWLEAHTQKPVLGVLPYLHDLHLDAEDALIESPTKQAQSRFKVRVLVYPRTSNHTD
FDPLRLHPDIDFDYVSLQTQASAQTQEIVADLLILPGSKNVRADLAFLREQGWDKQIAKH
LRYGGKLLGICGGYQMLGESIADPMGIEDTLGVSQGLGYLPITTEFKAEKQLRRVTGHLA
LQGQQVEVKGYEIHCGESQYLTSSDAAKSAPLRLKSESACDQQAEKPFADGCLSDDGQVL
GSYLHGLFDSPEACQLVLHWAGLENAQAIDINDIREQQLDRLADVLAEHLDMQKLASIIN
A