Protein Info for Shewana3_3169 in Shewanella sp. ANA-3

Annotation: ATPase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 857 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 6 to 855 (850 residues), 1435.5 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 68 (52 residues), 47.5 bits, see alignment 1e-15 amino acids 94 to 145 (52 residues), 39.4 bits, see alignment 3.5e-13 PF00004: AAA" amino acids 203 to 316 (114 residues), 49.4 bits, see alignment E=4.3e-16 amino acids 602 to 722 (121 residues), 39.5 bits, see alignment E=4.9e-13 PF17871: AAA_lid_9" amino acids 342 to 444 (103 residues), 117.7 bits, see alignment E=1.3e-37 PF07724: AAA_2" amino acids 596 to 759 (164 residues), 235.9 bits, see alignment E=1.7e-73 PF00158: Sigma54_activat" amino acids 600 to 720 (121 residues), 25.1 bits, see alignment E=8.3e-09 PF07728: AAA_5" amino acids 601 to 721 (121 residues), 50.8 bits, see alignment E=1.2e-16 PF10431: ClpB_D2-small" amino acids 766 to 846 (81 residues), 96.5 bits, see alignment E=4.8e-31

Best Hits

Swiss-Prot: 98% identical to CLPB_SHEON: Chaperone protein ClpB (clpB) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 77% identity to avr:B565_3766)

MetaCyc: 77% identical to protein disaggregase ClpB (Escherichia coli K-12 substr. MG1655)
RXN185E-10

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L024 at UniProt or InterPro

Protein Sequence (857 amino acids)

>Shewana3_3169 ATPase (RefSeq) (Shewanella sp. ANA-3)
MRLDRMTNKFQLAISDAQSLALGRDHQFIEPLHLMMALLNQDSGSIHPLLTQAGIRVSAL
RSLLSQELERLPQVEGTGGDVQLSQGLIRLLNLCDKLAQKRKDKYISSELFVLAALEGSD
ALAQCLKKSGATKELLEQTIEQVRGGQNVDDPNAEDQRQALKKFTVDLTERAEQGKLDPV
IGRDDEIRRTIQVLQRRSKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGIKNKRVLSL
DMGALIAGAKYRGEFEERLKAVLNELAQEEGQVILFIDELHTMVGAGKGDGAMDAGNMLK
PALARGDLHCVGATTLDEYRQYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKERYELH
HHVEITDPAIVAAATMSHRYVSDRKLPDKAIDLIDEAASSIRMQMDSKPESLDRLERRAI
QLKLEEQALAKENDEASRRRLEHLRVELHEVEAKASELNEIWRTEKAALAGTQHIKADLE
QARMDLEVARRAGDLTRMSELQYGRIPELEKQLDLASQAEMQDMTLLRNKVTDLEIAEVL
SKATGIPVSKMLEGEREKLLQMEVALHERVIGQNEAVDAVANAIRRSRAGLADPNRPIGS
FLFLGPTGVGKTELCKSLAKFLFDTESALVRIDMSEFMEKHAVSRLVGAPPGYVGYEEGG
YLTEAVRRKPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVIIMTSNL
GSDIIQEGFGHLSYSEMKSAVMNVVTHSFRPEFLNRIDESVVFHPLDAENIKHIASIQIA
SLRKRLAEKDYTLEITDEALSLIAEIGFDPVYGARPLKRALQQEMENPLAQKLLRGDLLP
GKPIKVSCAGGELVFEQ