Protein Info for Shewana3_3161 in Shewanella sp. ANA-3

Annotation: peptidase M16 domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 949 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF00675: Peptidase_M16" amino acids 63 to 187 (125 residues), 66.6 bits, see alignment E=2.4e-22 amino acids 536 to 670 (135 residues), 56.4 bits, see alignment E=3.3e-19 PF05193: Peptidase_M16_C" amino acids 220 to 395 (176 residues), 125.6 bits, see alignment E=2.1e-40 amino acids 686 to 858 (173 residues), 80 bits, see alignment E=2.1e-26

Best Hits

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 100% identity to shn:Shewana3_3161)

Predicted SEED Role

"Protease, insulinase family/protease, insulinase family"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L016 at UniProt or InterPro

Protein Sequence (949 amino acids)

>Shewana3_3161 peptidase M16 domain-containing protein (RefSeq) (Shewanella sp. ANA-3)
MYKGNTLKKWILAVAISAALAGCASQTSTQLPAGVKLIENVQLKDSEVGIPFKKYQLANG
LTVILHQDHSDPLVHVDVTYHVGSARELAGRSGFAHLFEHMMFQGSEHVADEQHFEVVTE
AGGTLNGSTNTDRTNYFETVPSNQLEKMLWLESDRMGFLLPALTSEKFEVQRETVKNERA
QRIDNQPYGRMSERFNQAMFPVGHPYSWPVIGWPEDLNRATVDDVKHFFQRWYGPNNATL
TIGGDFDELQALAWVNKYFGEIPRGPEVQPEPKTLVTLDKTRYISMEDNVHLPLIRIGFP
TVYASHPDEAALDLLANILGGGKTSLVYKNLVKDGYAVQASVSQPCQELACQMSIYALAN
PQKGATLAELEQRILDSINEFEQRGVTDDDLQKVKVQFEADTIFGLQSVKGKVSMLALNQ
TMFGEPNKIAVDLARYANVTKDDVMRVFKKYIKDKPMVVMSVVPQGMTALVAHPDNFTPQ
TLPVAYTAVEGDLPAAKLVSSFDRSKMPASGAAPVLKVPTIWTTKLANGIEVMGTQSSET
PTVELVIYLNGGHRLVPVEKAGLASLTAEMLNESTQKRSTEQLSQALEMLGSTVDFSASE
SQSTIKVSALTEHLDETLAILEEKLFQPAFNEADFARVKQQQLQQIQHMQSDPGYVANSA
LYSLLYGKNNAQGVSDAGTLDSVAALTLADVKAFYAEQYRGANAKIITVADLPESALLPK
LAGLSQWQGEASRLPPLKSFPALKGGTIYLIDKPGAAQSVINIAKRALPYDATGNYFKSY
LMNYPLGGAFNSRINLNLRENKGYTYGARSSFTGGVEVGDFVASSDVRTDVTAKAVNEFI
KEIKVYQQNGMTDTELGFMRNSVSQGQALDYETPYQKAGFMRMIQRYQLSQDFTTEQDKI
INTVTKDELNALAASELDISKMIILVVGDKAKIEADLATLGYPIETLVL