Protein Info for Shewana3_3105 in Shewanella sp. ANA-3
Annotation: aldehyde dehydrogenase (acceptor) (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to PUUC_ECOLI: NADP/NAD-dependent aldehyde dehydrogenase PuuC (puuC) from Escherichia coli (strain K12)
KEGG orthology group: K09472, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC: 1.2.1.-] (inferred from 100% identity to shn:Shewana3_3105)MetaCyc: 75% identical to 4-guanidinobutyraldehyde dehydrogenase / 4-aminobutyraldehyde dehydrogenase (Pseudomonas aeruginosa)
Gamma-guanidinobutyraldehyde dehydrogenase. [EC: 1.2.1.54]; Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.54, 1.2.1.19]
Predicted SEED Role
"Gamma-glutamyl-aminobutyraldehyde dehydrogenase (EC 1.2.1.-)" (EC 1.2.1.-)
MetaCyc Pathways
- superpathway of ornithine degradation (6/8 steps found)
- putrescine degradation IV (2/3 steps found)
- putrescine degradation I (1/2 steps found)
- putrescine degradation V (1/2 steps found)
- superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
- L-arginine degradation IX (arginine:pyruvate transaminase pathway) (1/4 steps found)
- L-arginine degradation VIII (arginine oxidase pathway) (1/4 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
- L-lysine degradation X (1/6 steps found)
- L-lysine degradation I (1/7 steps found)
- superpathway of L-lysine degradation (7/43 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Arginine and proline metabolism
- Geraniol degradation
- Limonene and pinene degradation
- Lysine biosynthesis
- Naphthalene and anthracene degradation
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-
Use Curated BLAST to search for 1.2.1.- or 1.2.1.19 or 1.2.1.54
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0KZW0 at UniProt or InterPro
Protein Sequence (498 amino acids)
>Shewana3_3105 aldehyde dehydrogenase (acceptor) (RefSeq) (Shewanella sp. ANA-3) MSTPKKRSDWESLAASLAINGKAYINGEYRDAAAGSTFDCVSPIDGRVLAKVASCDQMDA NIAVANAREVFESGVWSKTAPVKRKQVMIRFAELLEENANELALLETLDMGKPIRFSKAV DIAGAARAIRWSGEAVDKLYDELAPTAHNEIGMITREPVGVVAAIVPWNFPLLMACWKLG PALATGNSVILKPSEKSPLTAIRIAELAVQAGIPKGVLNVLPGYGHTVGKALALHMDVDT LVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFNDAPDLKAAAVAAAEAIAFNQG EVCTAGSRLLVESGVKDQLIELIAEELASWQPGHPLDPATVSGAVVDKQQLDTILSYIKA GQDEGASLVHGGQQVLAETGGVYVQPTIFSQVNNKMKIASEEIFGPVLSVIEFNGMEEAI AIANDTIYGLAAGVWTADISKAHKTAKALRSGMVWINHYDGGDMTAPFGGYKQSGNGRDK SMHSFDKYTEIKATWIAL