Protein Info for Shewana3_3045 in Shewanella sp. ANA-3

Annotation: adenylate cyclase-related protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 335 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details amino acids 56 to 79 (24 residues), see Phobius details amino acids 100 to 132 (33 residues), see Phobius details PF00211: Guanylate_cyc" amino acids 149 to 327 (179 residues), 30.3 bits, see alignment E=1.6e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to shm:Shewmr7_2949)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KZQ1 at UniProt or InterPro

Protein Sequence (335 amino acids)

>Shewana3_3045 adenylate cyclase-related protein (RefSeq) (Shewanella sp. ANA-3)
MAAFVFFRYAQSPELPQWAVGSADLATLAVYMGIIFGSLHWMSNLIADFSAINRLPYVFS
VIFKGLFLLLGATTLAYMTQFLNMWAIENHMSTLRQMLTAHILYSPSFQALIVYLVVVRV
SLAFVEQMALLVGPRILLNIGLGKYHKPRYEQRLFLYLDMVASTTHAESLGDYRFSRLIQ
DSFSLLSDTVTNNEAEIYRYMGDAVLIHWPLEEGVVHDRCMNIYFEFSQQLNWQRRYFEE
HYGFVPKFKAAAHCGQVVAAVVGVQKQEISFFSDVLNTLARLQDQCNPLGQRMLISGALA
GRLDNPNSEYRLTNLGPVKLKGKQHSIEVFGVSPL