Protein Info for Shewana3_3025 in Shewanella sp. ANA-3

Name: era
Annotation: GTP-binding protein Era (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00231: small GTP-binding protein domain
  • amino acids 44 to 207 (164 residues), 107.2 bits, E=7.5e-35
• TIGR00436: GTP-binding protein Era
  • amino acids 46 to 319 (274 residues), 342.1 bits, E=2.2e-106
• PF01926: MMR_HSR1
  • amino acids 48 to 164 (117 residues), 93.6 bits, E=3.5e-30
• PF02421: FeoB_N
  • amino acids 48 to 206 (159 residues), 43.1 bits, E=1.3e-14
• PF00009: GTP_EFTU
  • amino acids 48 to 213 (166 residues), 32.2 bits, E=3.3e-11
• PF04548: AIG1
  • amino acids 49 to 179 (131 residues), 29.9 bits, E=1.4e-10
• PF07650: KH_2
  • amino acids 248 to 324 (77 residues), 68 bits, E=2e-22

Best Hits

Swiss-Prot: 70% identical to ERA_HAEPS: GTPase Era (era) from Haemophilus parasuis serovar 5 (strain SH0165)

KEGG orthology group: K03595, GTP-binding protein Era (inferred from 99% identity to son:SO_1349)

MetaCyc: 66% identical to 30S ribosomal subunit maturation GTPase Era (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]

Predicted SEED Role

"GTP-binding protein Era" in subsystem Bacterial Cell Division or Universal GTPases

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.15

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6

Sequence Analysis Tools

See A0KZN1 at UniProt or InterPro

Protein Sequence (339 amino acids)

>Shewana3_3025 GTP-binding protein Era (RefSeq) (Shewanella sp. ANA-3)
MTKKTDLPAVDAANASNEPSLDELLARMNAASAAAPSVHYDVTYCGMVAIIGRPNVGKST
LLNRLLGQKISITSKKPQTTRHRIMGIHTDGPRQIVFIDTPGLHIEEQRAINRLMNRAAA
SSLADVSMVIFVVDGMTWTADDEMVLSKLRRGGEERKTVLAINKVDNIKDKEALFPYLEE
VAKKYPFDEILPISASKGTNVKRILEMAAESLPENPFFFPEDYVTDRSQRFMASEIVREK
LMRFLGDELPYDATVEIEQFKMMENGVYQINALILVEREGQKRMVIGSKGERIRTIATQA
RLDMETLFDNKVFLEVWVKVKSGWADDERALRSLGYGDD