Protein Info for Shewana3_2923 in Shewanella sp. ANA-3

Annotation: multi anti extrusion protein MatE (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 62 to 87 (26 residues), see Phobius details amino acids 100 to 122 (23 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details amino acids 200 to 221 (22 residues), see Phobius details amino acids 244 to 266 (23 residues), see Phobius details amino acids 268 to 271 (4 residues), see Phobius details amino acids 278 to 301 (24 residues), see Phobius details amino acids 323 to 342 (20 residues), see Phobius details amino acids 368 to 388 (21 residues), see Phobius details amino acids 397 to 417 (21 residues), see Phobius details amino acids 423 to 442 (20 residues), see Phobius details PF01554: MatE" amino acids 28 to 189 (162 residues), 78.4 bits, see alignment E=5.2e-26 amino acids 250 to 407 (158 residues), 59.7 bits, see alignment E=3e-20 PF14667: Polysacc_synt_C" amino acids 143 to 285 (143 residues), 30.2 bits, see alignment E=4.7e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to shn:Shewana3_2923)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KZD0 at UniProt or InterPro

Protein Sequence (450 amino acids)

>Shewana3_2923 multi anti extrusion protein MatE (RefSeq) (Shewanella sp. ANA-3)
MTAISHSATDQRLLQEPIAKLFWRYTIPTIASMLVTGVYVTIDGIFVGHYLGETGLAGMM
LAYPVGAILYAVGAMIGMGSAALVSINLGQGHVAKARKLLGNAFSLCLLAGAFFALIGGI
FSRDILIALGAEGEILENANEYLFWYFALCHFPIISMAFTTLLRNDGRPSMVTFVLILGG
VLNTFLDWLFIVVFPFGLAGAAIATMLSQAVTGLLCLQHFFGARTQLKINLEQMKLKLDN
CLNIARVGLPSFLMNLYLSIVLTLHNTAFLWVGGPLHVAAYGVVSYTEAFFYLIFEGIAL
GTQPIYSFNAGAGRFDRVKQARNIAFGMTLLTAGLCLVLIYSRPEWLVYLFAGDNPSLTP
VAIEGMRWYFWGLPMEGLILVGASFFQAINCSKQASILTGAKLLLIAAIIYCFAWAFGVI
GVWVSLATCSTMLVIWMFIAMGRLQVNAKV