Protein Info for Shewana3_2778 in Shewanella sp. ANA-3

Annotation: fumarylacetoacetate (FAA) hydrolase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 PF18288: FAA_hydro_N_2" amino acids 1 to 78 (78 residues), 101 bits, see alignment E=4.1e-33 PF01557: FAA_hydrolase" amino acids 82 to 323 (242 residues), 122.2 bits, see alignment E=2.6e-39

Best Hits

KEGG orthology group: None (inferred from 99% identity to she:Shewmr4_2604)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KYY6 at UniProt or InterPro

Protein Sequence (328 amino acids)

>Shewana3_2778 fumarylacetoacetate (FAA) hydrolase (RefSeq) (Shewanella sp. ANA-3)
MKLASYNNGRRDGQLMLVSRDLTQTVAVPAIAHTMQQLLDGWDLLKPQLQELYDALNEGK
LPNAQAFDEAKCLSPLPRAYQWADGSAYVNHVELVRKARGAEMPETFWTDPLFYQGGSDS
FIAPKADIPLASEDWGIDFESEIAVITDDVPMGVSVENATAHIKLLMLVNDVSLRNLIPA
ELAKGFGFFQSKPSSSFSPVAITPDELGHRWEDSKVHLPLITHLNGELFGRPNAGVDMTF
NFSQLVSHVAKTRPLGAGAIIGSGTISNYDRSAGSSCLAEKRMLEVIADGKASTPFMRFG
DTVRIEMLDDNGASIFGSIDQKVVEYKA