Protein Info for Shewana3_2686 in Shewanella sp. ANA-3

Annotation: pyridoxal-dependent decarboxylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 549 TIGR03799: putative pyridoxal-dependent aspartate 1-decarboxylase" amino acids 8 to 532 (525 residues), 965.4 bits, see alignment E=3.1e-295 PF00282: Pyridoxal_deC" amino acids 69 to 443 (375 residues), 160.6 bits, see alignment E=7e-51 PF00266: Aminotran_5" amino acids 218 to 431 (214 residues), 23.4 bits, see alignment E=4.2e-09 PF01212: Beta_elim_lyase" amino acids 236 to 362 (127 residues), 28.4 bits, see alignment E=1.5e-10

Best Hits

Swiss-Prot: 66% identical to PANP_ALIF1: Aspartate 1-decarboxylase (panP) from Aliivibrio fischeri (strain ATCC 700601 / ES114)

KEGG orthology group: K01580, glutamate decarboxylase [EC: 4.1.1.15] (inferred from 100% identity to shn:Shewana3_2686)

Predicted SEED Role

"Glutamate decarboxylase, eukaryotic type (EC 4.1.1.15)" (EC 4.1.1.15)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KYP4 at UniProt or InterPro

Protein Sequence (549 amino acids)

>Shewana3_2686 pyridoxal-dependent decarboxylase (RefSeq) (Shewanella sp. ANA-3)
MTQKLPRQAIASEDSLMRIFTVPEDAESTLSIIEQKLSEDLAGFLGDSIAALEKPLSEIE
TDFQAFEIPSQPRFVSDYTDEIMQNLVAHSVHTAAPSFIGHMTSALPYFVLPLSKMMVGL
NQNLVKIETSKAFTPLERQVLGMMHHLIYAQDDDFYRNWMHSANHSLGAFCSGGTVANIT
ALWIARNQLLKADGDFKGVTREGLIKALRHYGFDDLAILVSERGHYSLGKAVDLLGIGRD
NIISIPTDGNNKVDVAKMREVAAELANKRIKVMAIVGVAGTTETGNIDPLRELAALASEL
NCHFHVDAAWGGASLLSNKYRHLLDGIELADSVTIDAHKQMYVPMGAGMVLFKNPEFAHA
IAHHAEYILRRGSKDLGSQTLEGSRPGMAMLVHACLQIIGRDGYEILINNSLEKARYFAE
QIDAHPDFELVTAPELCLLTYRYVPAEVQAAMQVAIDQGDKVKLARFNELLDGLTQFIQK
HQREQGKSFVSRTRIQPARYFRQPTVVFRVVLANPLTSHEILNRVLIEQGEIAALDKEFL
PALLAMANE