Protein Info for Shewana3_2522 in Shewanella sp. ANA-3

Annotation: multi-sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1146 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 38 to 58 (21 residues), see Phobius details amino acids 65 to 86 (22 residues), see Phobius details amino acids 115 to 133 (19 residues), see Phobius details amino acids 154 to 174 (21 residues), see Phobius details amino acids 188 to 213 (26 residues), see Phobius details amino acids 238 to 254 (17 residues), see Phobius details amino acids 275 to 299 (25 residues), see Phobius details amino acids 320 to 348 (29 residues), see Phobius details amino acids 378 to 397 (20 residues), see Phobius details amino acids 404 to 427 (24 residues), see Phobius details amino acids 434 to 452 (19 residues), see Phobius details amino acids 481 to 500 (20 residues), see Phobius details PF12860: PAS_7" amino acids 629 to 742 (114 residues), 146.6 bits, see alignment E=6.8e-47 PF00512: HisKA" amino acids 783 to 849 (67 residues), 38.2 bits, see alignment 2.5e-13 PF02518: HATPase_c" amino acids 894 to 1003 (110 residues), 77.1 bits, see alignment E=2.9e-25 PF00072: Response_reg" amino acids 1026 to 1138 (113 residues), 37.5 bits, see alignment E=4.8e-13

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 100% identity to shn:Shewana3_2522)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KY82 at UniProt or InterPro

Protein Sequence (1146 amino acids)

>Shewana3_2522 multi-sensor hybrid histidine kinase (RefSeq) (Shewanella sp. ANA-3)
MNLTLVVAVIAICYVSLLFLLAWGAERWFSGVTKKLQVGIYGLSLAVYCSSWSFLGTVGQ
SANDFWSFIPIFIGPIIIFTLGFGMLRKMVLVSKAQNITSVADFIAARYGKSQTLAAIVT
LIALFGIMPYIALQLKAMVFSLNLFQPADDPLNGITIPLLITALLAIFAILFGTRKLDAT
EHNPGMMLAIAFESLVKLAAFLLVGIVISFGVFDGFGDIWQQASEKALINYPNPRIEALM
PELLVGMAAFLCMPRQFHVMVVECADESVLSKGRWLFPLYLALFGLFVGPLALAGKVILG
DSVAADTYVINLPLALDHPLLAVIALLGTLSAATGMVIVAVVTISVMVSNEWLVPVMLRT
GNIREKNFSQFSQMLLNARRLAIVIILGLGYGSYLALADSDSLSHLGMLSFGAFAQLAPA
LVGGLYWKHGNRAGVFLGLSVGFGLWFYIMLSGMNDGQNVATLLSSNIDLLDAITPNVRD
ALTALFANIACYILGSIWFRAGVAERIQASAFVSPGKLKNNANKKNGPISQQDLLILASR
FVSPTRAYESFSRFSTEAVKSDSWHKAATPELIAHTERLLAGVLGASSASLVMDSVLQGR
DLALDEVFSLVDEASSKIMLSQDMLRGAIEHAYEGMSVIDSDLNLVAWNYKYVELYQYPE
GFLQQGMPIGEVIRFNAARGYCGEGDIESQVEKRVQHMRNGTPHTSERQRKDGKVIKIQG
NPMPDGGFVMTFTDITQYREQERALLEANETLESRVKERTYELAMLNSELLEAKAQEEMA
NASKSRFLAAVGHDLMQPLNAARLFTASLSQYPNLDREARTTLSHVNSSLKTAGELLTDL
LDISKLDSGMVEVNRRDFAISELLNGLSVEFEAMAADNQIRFKMVPCSATVNSDPSLLRR
VLQNFLTNAYRYARGGRVLFGCRHRGSELEIQVLDTGCGIDEHETREIFKEFKRLNNPRS
KSVSGLGLGLAIADRISRVLNHSIQVSSQLGRGSVFSISVPLGETVRQPQVKALPSLLQP
LSGIKVLCIDNEEAILAGLESLLSRWQCEVICAKDLADARIKLGLKGVAPDIVLADFHLD
DGQNGVDAMDGIRALYGKELPGILITANTRKELVEDVQRRGYHYMAKMIKPAALRALISS
LVKASR