Protein Info for Shewana3_2341 in Shewanella sp. ANA-3

Annotation: molybdopterin oxidoreductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 854 PF04879: Molybdop_Fe4S4" amino acids 56 to 107 (52 residues), 25.2 bits, see alignment 2e-09 PF00384: Molybdopterin" amino acids 111 to 535 (425 residues), 89.1 bits, see alignment E=4.5e-29 PF01568: Molydop_binding" amino acids 752 to 843 (92 residues), 50.1 bits, see alignment E=3.8e-17

Best Hits

KEGG orthology group: K00183, molybdopterin oxidoreductase, molybdopterin binding subunit [EC: 1.2.7.-] (inferred from 100% identity to shn:Shewana3_2341)

MetaCyc: 100% identical to respiratory arsenate reductase large subunit (Shewanella sp. ANA-3)
Arsenate reductase (donor). [EC: 1.20.99.1]

Predicted SEED Role

"Respiratory arsenate reductase, Mo binding subunit (ArrA)"

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.2.7.-

Use Curated BLAST to search for 1.2.7.- or 1.20.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7WTU0 at UniProt or InterPro

Protein Sequence (854 amino acids)

>Shewana3_2341 molybdopterin oxidoreductase (RefSeq) (Shewanella sp. ANA-3)
MKKENQVNLGRRQLLKSTAAGTVLTGIGGTLSFTPIVEGIAAELPAPLRRTGVGEWLATT
CQGCTSWCAKQIYVMDGRALKVRGNPNSGVHGMSSCPRQHLSLQQVYDPDRLRTPMMRTN
PKKGRDQDPKFVPISWDKALDMLADKIIALRVANEPHKYALLRGRYSHINDLLYKKMTNL
IGSPNNISHSSVCAEAHKMGPYYLDGNWGYNQYDVKNAKFILSFGADPIASNRQVSFYSQ
TWGDSLDHAKVVVVDPRLSASAAKAHKWIPIEPGQDSVLALAIAHVALVEGVWHKPFVGD
FIEGKNLFKAGKTVSVESFKETHTYGLVEWWNQALKDYTPEWASKITGIDPKTIIAIAKD
MGAAAPAVQVWTSRGAVMQARGTYTSISCHALNGLFGGIDSKGGLFPGNKTPLLKEYPEA
KAYMDEIAAKGVKKEKIDQRGRLEFPALAKGKSGGGVITANAANGIRNQDPYEIKVMLAY
FNNFNFSNPEGQRWDEALSKVDFMAHITTNVSEFSWFADVLLPSSHHMFEKWGVLDSIGN
GVAQISIQQPSIKRLWDTRIDESEIPYMLAKKLADKGFDAPWRYINEQIVDPETGKPAAD
EAEFAKLMVRYLTAPLWKEDASKYGDKLSSWDEFVQKGVWNSSPYKLEARWGKFKTETTK
FEFYSKTLEKALQSHADKHKVSIDEVMKACDYQARGHLAFIPHYEEPYRFGDESEFPLLL
VDQKSRLNKEGRTANSPWYYEFKDVDPGDVANEDVAKFNPIDGKKFGLKDGDEIRITSPV
GMLTCKAKLWEGVRPGTVAKCFGQGHWAYGRYASAKFGVTPRGGSNNDLIADRYDRLSGA
SAFYGHIRVRVEKV