Protein Info for Shewana3_2152 in Shewanella sp. ANA-3

Annotation: DNA-binding transcriptional regulator HexR (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 PF01418: HTH_6" amino acids 1 to 76 (76 residues), 100.8 bits, see alignment E=5e-33 PF01380: SIS" amino acids 124 to 252 (129 residues), 82.8 bits, see alignment E=2.9e-27 PF13580: SIS_2" amino acids 172 to 209 (38 residues), 28 bits, see alignment 3.1e-10

Best Hits

Swiss-Prot: 74% identical to HEXR_ECOLI: HTH-type transcriptional regulator HexR (hexR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to sbl:Sbal_2242)

Predicted SEED Role

"Phosphogluconate repressor HexR, RpiR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KX63 at UniProt or InterPro

Protein Sequence (284 amino acids)

>Shewana3_2152 DNA-binding transcriptional regulator HexR (RefSeq) (Shewanella sp. ANA-3)
MNTLEKVQKSLTHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDT
KGFPDFKLHLAQSLANGTPYVSRHVEEDDSPESYTTKIFESSMASLDTARQSLDVTAINK
AVDILTQAKTISFFGLGASASVAHDAQNKFFRFNVPVICFDDVLMQRMSCINSNEGDVVV
LISHTGRTKSLIEIARLARENGAAVIGITARNSPLSMECTLPVTMEVPEDTDMYLPMASR
LAQLVTIDVLATGFTLRRGPRFRDNLKRVKEVLKESRINKDPIL