Protein Info for Shewana3_2026 in Shewanella sp. ANA-3

Annotation: type III restriction enzyme, res subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1138 PF04313: HSDR_N" amino acids 208 to 320 (113 residues), 33.9 bits, see alignment E=9.6e-12 PF04851: ResIII" amino acids 361 to 509 (149 residues), 109.7 bits, see alignment E=4.5e-35 PF00270: DEAD" amino acids 363 to 509 (147 residues), 34.3 bits, see alignment E=5.9e-12 PF18766: SWI2_SNF2" amino acids 365 to 575 (211 residues), 56 bits, see alignment E=1.4e-18 PF08463: EcoEI_R_C" amino acids 980 to 1104 (125 residues), 49.2 bits, see alignment E=2e-16

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 100% identity to shn:Shewana3_2026)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KWT8 at UniProt or InterPro

Protein Sequence (1138 amino acids)

>Shewana3_2026 type III restriction enzyme, res subunit (RefSeq) (Shewanella sp. ANA-3)
MKQSMNFEFLRKNWPELADFGAYAEEYAFSDPQSALIKLRSYSEYIVNFIYQKLNLPCLP
KASFHEKLVGEDFVQLASSAVLDKFHLIKTLGNKAAHENKGASNDALFAVKQSHQLGTWF
YCSYHNLQACTVPAFIELSEEFLTTSKLKKKLEQSDALYQQAMAELERQRLVNEQMFAAA
KQATAVKDTPVFEAFATNSQLLSSSLNFNEAETRKYLIDMELRDIGWEVSKDNKSTDQVG
QEVEVKHQPTNTGIGYVDYVLWDDDGLPLAVVEAKKTSKDARIGKKQAKDYADALEKHYG
QRPVIFYTNGHDIYIWDDAQGYPPRKIYGFYSKSSLQHLVKFQRIEKKKLTDVAIDTEVA
GRRYQLETISRVHETFELKRRKALVVQATGTGKTRVSIALAKSLMDAKWVKRILFLCDRK
ELRKQADKAFVQFLGVKPYVVGKSDKKYKDTARVFIATYPGMMGIYEDFDVGYFDLIIAD
ESHRSIYNVFGNLFKYFDCLQVGLTATPVEMVSRSTCNLFDCDYKEPTANYPLEKAIGEG
HLVPFEIVTMTTKFMREGMNQRSLSDEQIAELEAQGEDPNEFEFESAEIDNAVLNKDTNR
KILRNLMENGIKDKDNQLIGKSIIFARKINHARLLKELFDEMYPELSQGFCEVIHSEEPR
AEALIDQFKITEEEKAKDSSLPDPITLAISVDMLDTGIDVPSVVNLVFAKPVKSKVKFWQ
MIGRGTRLCEDLFGKGKHKTRFLIFDHWNNFDYFEFNYEEVEPSNTKSLAQKRFELRLQL
ASAALKKLELNAFSQTIKLLQQDINALNTRNINVRDHWAIVTQLSDVKVLEQFAKPTVAL
LESQIAPLMNWLVIKGQSKAFRWDCLIAQTQCELLLNREAIGELKLEVQSVLERLPKNTA
QVQAKATEIKFLMDSNSWLNITFYQLEQHRLALREIMYLLEGDILPPNPGPKYIDVKEDN
SHIEYKARAANIHTVDYQIYQQKVQEALQPIFDSNPVIQKIRKGQAVTVSEIAQLNGIIH
AKYANLDIETLKTFYPDTTEPLDKLLRSIVGMDTQYIEQSFTALLQKHRMPPQAMRVIDM
LIGHIARSGGIKMADLDQAPYNKIYEGILGSSEDDVFSLLRSLELPIPLTKAEMTAKN