Protein Info for Shewana3_1785 in Shewanella sp. ANA-3

Annotation: glutamate dehydrogenase (NAD) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1614 PF21075: GDH_ACT1" amino acids 34 to 176 (143 residues), 159.2 bits, see alignment E=2.3e-50 PF21073: GDH_HM1" amino acids 345 to 404 (60 residues), 86.4 bits, see alignment (E = 3.9e-28) PF21076: GDH_ACT2" amino acids 408 to 497 (90 residues), 119.3 bits, see alignment 3.5e-38 PF21079: GDH_HM2" amino acids 503 to 547 (45 residues), 57.4 bits, see alignment (E = 4.5e-19) PF21077: GDH_ACT3" amino acids 553 to 625 (73 residues), 97.9 bits, see alignment 8.7e-32 PF21078: GDH_HM3" amino acids 649 to 714 (66 residues), 95.7 bits, see alignment (E = 5.8e-31) PF05088: Bac_GDH_CD" amino acids 728 to 1222 (495 residues), 909.7 bits, see alignment E=1.6e-277 PF21074: GDH_C" amino acids 1267 to 1604 (338 residues), 423.8 bits, see alignment E=2.1e-130

Best Hits

KEGG orthology group: K00260, glutamate dehydrogenase [EC: 1.4.1.2] (inferred from 62% identity to aha:AHA_2288)

Predicted SEED Role

"NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form" in subsystem Glutamate dehydrogenases or Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis (EC 1.4.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KW49 at UniProt or InterPro

Protein Sequence (1614 amino acids)

>Shewana3_1785 glutamate dehydrogenase (NAD) (RefSeq) (Shewanella sp. ANA-3)
MALKDAMPSVLLENVVSLIHAKVPNSQAKQVEQFATCLYAHMSKDDLNARNDSDLYGAVL
SLWNALNKTPKGETHLRVFNPSQSKHGWQSTHSIIEVIQPDMPFLVDSVGMALNRMGITA
HMMLHTPLAIERSAQDVTKVTYLNQSPDSTEHVAVFLIEIDRQSSSVDIKALEREIQSVL
GDVAASVNDWSAMSAKLSETIKELPKRPFPGEKQELEEAINFLTYLNNHHFTLLGYRQYD
LKRVEGDVELVPNMASSLGLMNKHHKTQPEQGLLLSSFSDSARKEALDHSLLILTKSSAK
SRVHRPAYVDYIGIKRFDKKGNVVGEDRFIGLYASNVYNRSPREIPLLNEKVQRVLDRSG
LTPRSHDYKALLNILENLPRDELIQANVDDLAHTAHGVLEMQDRDKLKLFVRKDGFGRFL
SCLVYVSKDRYNTKLRQDTQRILAQHFNSKEDVEFTTYFSESTLARTHYIVKVDNNNMDV
DVAAIENNLIEAARSWEDKLNTALNTALGEEAGTHLMKRYANAFEQSYKEDVLPSSAVVD
MQQLEALDDEHKLGMLFYQPQEAALNDNKVRLKLFHKDEPIHLSDVLPMLENFGLRVINE
RPYEVTTSDGSTFWILDFLMTVKVTNTDNIADSQDRFQTALSQVWQKKLEDDGFNRIILA
SGLTGREVSVLRAYAKYMRQIDATFSQAYIEETFGRYPQIADLLVKMFIRKFNPKLKTRT
LGKFMEQINLRLDEVSSLDDDRIIRRYLDLINATLRTNFYQLDAKGESKSYISFKFMPSL
IPEMPRPLPKFEIFVYSPRVEGVHLRYGKVARGGLRWSDRREDFRTEVLGLVKAQQVKNT
VIVPVGAKGGFVCKQLPTEGGREAFFTEGQECYRIFIRALLDITDNIVNGEIVHPVDVVR
HDEDDPYLVVAADKGTATFSDIANAISQEYNFWLGDAFASGGSNGYDHKKMGITARGGWE
SVKRHFREVGIDCQTTDFSCLGIGDMAGDVFGNGMLLSKHTKLVAAFNHMHIFVDPNPDT
AASYEERARLFALPRSTWEDYNSKLISKGGGIFLRSSKSIPLSAEMKQMLETEKTSMTPT
ELMKELLKMPVDLIWNGGIGTYVKSSRETHAEVGDRANDALRVNGRELRAKIVGEGGNLG
CTQLGRIEYAANGGRINTDFVDNVGGVDCSDNEVNIKILLNALVAEGELTLKQRNRLLEE
MTEEVGQIVLQDCKDQTRTISVTQVRGAEQLKEQIRFIQYLEKEGKLDRALEFLPSEEEL
AERLANGRALTRPELSVLVAYAKMVLKEQLLTQEITEDTLLSQLLIAYFPKQLQELYSHR
MVTHPLRGEIIATSLANELVNDMGLNFVQRMQDETGASVADAAICYTMAREVFGLAELTK
AITDLNGIVPAVVQGEMLHQLRRNMRRACRWFLRHRNRTWSIEQTVAFFKPVFEQIKANV
HSYLVEEEAAGIQAEINALIKENVPQEVATVVANMSTLFSALDIAQIAQAEEKTVELVAE
TYFKLGARVELHWFLEQISAQPVANHWQALARAAFREELDWQQRALTSVVLRTCSETCDA
QSVISQWIDTNQALLERWFHMLADFKTSQSHEFAKFSVALRELNLLILHCEGHK