Protein Info for Shewana3_1778 in Shewanella sp. ANA-3

Annotation: carboxy-terminal protease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 683 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF17804: TSP_NTD" amino acids 52 to 232 (181 residues), 201.4 bits, see alignment E=3.4e-63 TIGR00225: C-terminal processing peptidase" amino acids 195 to 554 (360 residues), 359.6 bits, see alignment E=7.4e-112 PF00595: PDZ" amino acids 238 to 319 (82 residues), 37.1 bits, see alignment E=6.9e-13 PF03572: Peptidase_S41" amino acids 363 to 532 (170 residues), 159.9 bits, see alignment E=8.6e-51 PF11818: DUF3340" amino acids 538 to 672 (135 residues), 129.9 bits, see alignment E=1.8e-41

Best Hits

KEGG orthology group: K03797, carboxyl-terminal processing protease [EC: 3.4.21.102] (inferred from 100% identity to shn:Shewana3_1778)

Predicted SEED Role

"Tail-specific protease precursor (EC 3.4.21.102)" (EC 3.4.21.102)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.102

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KW42 at UniProt or InterPro

Protein Sequence (683 amino acids)

>Shewana3_1778 carboxy-terminal protease (RefSeq) (Shewanella sp. ANA-3)
MRKLTLATSIATVFVGFSAWAVPPTIQISELPTLKQEAQHKVASKRVTDLYTRSHYHRFA
LDDAFSAQIFDRYLQQLDYRRNVLTQADVDSFKPYTNQFDDMLSSGDLDPAYKMFDLVQK
RRYEGFVYALSLLDKEMDFTVPGDAYEYDREDAAWPKDQAEINELWRQRVKYDALNLKLT
GKKWPEIVDILQKRYNNAIKRLTQTNSEDVFQAVMNAFSRSIEPHTSYLSPRNAERFQME
MNLSLEGIGAQLQLEDDYTVIKSLIAGGPAASSEKLSPEDKIVGVGQEGGEIVDVIGWRL
DDVVDLIKGPKGSKVILQILPKKGGSNAKPFNLTLVRDKIRLEDRAATSKIIEPKDGEYA
NRKVGVIQIPGFYMNLSQDVEKELVKLNEAKVEGVVIDLRGNGGGALTEAVLLTGLFIDM
GPVVQVRDADGRVSAHRDNDGKTTYAGPLTIMVDRYSASASEIFAAALQDYDRALIVGES
SFGKGTVQQHKSLGRIYDMYEKPIGHVQYTIQKFYRINGGSTQLKGVTPNIAYPSALEPG
EYGEAEEKNALPWDKVPMAQYGTLNDITPELVASLEKKHLARIQNDVEFNYINQDIADFK
KHHKEKTVSLVESERIASREADEKKVLDRTNERRVAHGLAAVKSMEDIKDKDDVEAPDAF
LDETAYITLDMADAKKLANAGTK