Protein Info for Shewana3_1668 in Shewanella sp. ANA-3

Annotation: hydroxymethylglutaryl-CoA lyase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00682: HMGL-like
  • amino acids 16 to 282 (267 residues), 176.5 bits, E=4e-56

Best Hits

Swiss-Prot: 62% identical to HMGCL_CHICK: Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) from Gallus gallus

KEGG orthology group: K01640, hydroxymethylglutaryl-CoA lyase [EC: 4.1.3.4] (inferred from 100% identity to shn:Shewana3_1668)

MetaCyc: 59% identical to Hydroxymethylglutaryl-CoA lyase, mitochondrial (Homo sapiens)
Hydroxymethylglutaryl-CoA lyase. [EC: 4.1.3.4]

Predicted SEED Role

"Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.1.3.4)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• mevalonate degradation (1/2 steps found)
• ketogenesis (3/5 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Synthesis and degradation of ketone bodies
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.4

Sequence Analysis Tools

See A0KVT2 at UniProt or InterPro

Protein Sequence (310 amino acids)

>Shewana3_1668 hydroxymethylglutaryl-CoA lyase (RefSeq) (Shewanella sp. ANA-3)
MSALDLSTLSASSDRVSLFEMGPRDGLQNEAAVPTQAKVALIESLADAGVKRIEAGSFVS
PKWVPQMADSGDVLRQIRRQAGVVYSALTPNVKGLELALDAKASEVAIFGAASQSFSQRN
INCSIEESIERFIPLMDMAKAANIPVRGYVSCVLGCPYEGEIAASEVARVSEILYKMGCY
EISLGDTIGVGTPLKARKMLQAVMERVPVEMLALHFHDTYGQALANITACLDLGVRSFDA
SVAGLGGCPYAKGASGNLASEDLVYMLHGLGLKTGIDLEKLALAGFGISKQLNRLNGSKV
ANAILQGAKA