Protein Info for Shewana3_1619 in Shewanella sp. ANA-3

Annotation: serine/threonine protein kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 941 transmembrane" amino acids 330 to 350 (21 residues), see Phobius details PF00069: Pkinase" amino acids 76 to 287 (212 residues), 123 bits, see alignment E=2.2e-39 PF07714: PK_Tyr_Ser-Thr" amino acids 78 to 266 (189 residues), 95.8 bits, see alignment E=4.1e-31

Best Hits

KEGG orthology group: K08884, serine/threonine protein kinase, bacterial [EC: 2.7.11.1] (inferred from 100% identity to shn:Shewana3_1619)

Predicted SEED Role

"Serine/threonine protein kinase PrkC, regulator of stationary phase" in subsystem Conserved gene cluster associated with Met-tRNA formyltransferase

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.1

Use Curated BLAST to search for 2.7.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KVN3 at UniProt or InterPro

Protein Sequence (941 amino acids)

>Shewana3_1619 serine/threonine protein kinase (RefSeq) (Shewanella sp. ANA-3)
MSSLYEHFSRLSELSSSEQEAYLQTLKHDDYSLYQRLCTMLNIPEMDTTQLFQAGIQQAA
EGIFDILDEGDIVGKYKVIRQIGQGGMGHVYLGERQDGTYSQVVAIKAVPLALMSAEAGS
FFNYEAQALASLSHPNVVTILDAGQDSRGMAYVVMPYIQGESITQYCMPLISVADKVRVF
IQVLDGIIHSHANQVLHRDIKPDNILVDDDGRVHVIDFGISKLMGEQGNGDQFYLNALSF
EYASPEQKAGGKVTVASDIYSLGKVLNILVPDDKIIGRIAAKASAAQVEERYQTVAELKT
ELFNYLASRPILAYPSRGYNAGLWFKRHRLAVSMTIGLCIAGSVTGYHYYEAKLESMQQA
QLADSNLKLAEAMLAQVDVKVVSEIERQRALVESASHVELNLLPKAQAVRFTLSLMEANK
VIGDYVKARLESDKLINLTSGLPEYSTEHLIATKFQLELDIMDNRRQDIEKRLEMLNNAV
ASLPNTGDNRLFALVDWEIGSAPLSNKAYHQLFQSVIPHLRAKDINQEILLQHASIIASS
NTVDQDKLQQLEALLDKSESDIASVSAKHWASLLHDWYIMSNLQGKQSVENLNHRIVSNT
GLLNSLYDNKHPSVYVLAILAKQSASINRFKLGDIIDEIYNSIDADTLPAVYRTNYFIIE
LTNAISERRFADAYQVMVTVSPELSSYGENALNYYLQFSVFANAFDKQELYLNQLYLLSE
HYKAKGNIGHAGYFAYSQCSSSAKQFEPDILDIKNGLNACNEALPFYRKHYGEASNFYIL
SLISKLQLQIQLGDTADVETLINMLEPKLAEITYPATQVIYLKTMALAHLALKDLDAADE
LINKLSNLANVTSYDLLLVKLERLQSAGELFDVKTELDRIGSLNCEALSKEQLNRLKKYI
SDDEFSMLDLCPNSVGWNDFAKLPEQTLKIYSSVDDFISYL