Protein Info for Shewana3_1586 in Shewanella sp. ANA-3

Annotation: peptidyl-dipeptidase Dcp (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 715 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF01432: Peptidase_M3" amino acids 269 to 712 (444 residues), 427.3 bits, see alignment E=5.6e-132

Best Hits

Swiss-Prot: 46% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 100% identity to shn:Shewana3_1586)

MetaCyc: 46% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

Compare fitness of predicted isozymes for: 3.4.15.5

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KVK1 at UniProt or InterPro

Protein Sequence (715 amino acids)

>Shewana3_1586 peptidyl-dipeptidase Dcp (RefSeq) (Shewanella sp. ANA-3)
MRKSVITTAVAAALLLGACSEKPAANTEAANAVATQAAASTQADATNVLLSKSPLQDQAP
QFNLIKSSDYAPAFAQGIKEHEAEIAAIIANKQAPTFDNTILAMETSGELLTRVSRTFFN
LAGLISDDDFQKTEADLAPKLSAHRDNIYLDPSLFARVETVYQQRAGLNAEDKRLVEFYY
EQFVRAGAKLSDADKAKMRDFNAELATLATEFSQNSLKSFKDDVIVVTDKAQLDGLSDSE
IATLAAAAQAAGKTGYLITLVNTTRQPILASLNNRELRQKVWETSAHRAVASNGPLIVKM
AQLRAKKANLLGFDTWAAYAVADQMAKTPSAVYEILDDLAPKALAHAKADAADIQAEIKK
AGGNFELQPWDWAYYAEKVRQQKYALDESSIKPYFEFNSVLKDGLFFAMHKLYGISVKPR
TDLPVWNSDVLAFEVFDKDNSSIGLFYLDPYAREGKGGGAWMDEFVTQSGLLGTKPVVYN
ALNIPKPADGPTLMTFDEVTTMFHEFGHAVHGLFSKVKYPSVAGTSTARDFVEFPSQVNE
DWNIDPAVIANYAKHYQTGEPIPKALLDKILASNKFGQGFDTVEYLAAALLDMEWHSIGA
DTQNKDVEQFEHQVLAKHGLDFAPIPPRYKSSYFSHAFSGGYSAGYYAYLWTEVFAADAF
AYMGQHGGLKAENGDKFRDAVLSKGNSEDLMQDYIHFTGQKPTTDALLKRRGLVD