Protein Info for Shewana3_1585 in Shewanella sp. ANA-3

Name: cpdB
Annotation: bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 685 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR01390: 2',3'-cyclic-nucleotide 2'-phosphodiesterase" amino acids 31 to 680 (650 residues), 906.5 bits, see alignment E=4.7e-277 PF00149: Metallophos" amino acids 32 to 278 (247 residues), 44 bits, see alignment E=3.6e-15 PF02872: 5_nucleotid_C" amino acids 376 to 577 (202 residues), 47.7 bits, see alignment E=1.8e-16

Best Hits

KEGG orthology group: K01119, 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC: 3.1.4.16] (inferred from 100% identity to shn:Shewana3_1585)

Predicted SEED Role

"2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16)" in subsystem Purine conversions (EC 3.1.4.16)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.4.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KVK0 at UniProt or InterPro

Protein Sequence (685 amino acids)

>Shewana3_1585 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein (RefSeq) (Shewanella sp. ANA-3)
MLNKKLLAVMITAALGVSACGSDDEQIVQADLRVLETTDLHTNIMDFNYYSGKEDPTIGL
ARTASLIHAARKEAKNSVLVDNGDLLQGSPMGDYMAKVGLQMGDVHPAYKAMNLLDYEVG
NIGNHEFNYGLDFLNKSLHGAEFPYINANVYCTDDNGCWNDVKKGEHLFTPYIIKEKQIV
DSEGNNQTIKIGYIGFVPPQILLWDKQNLTGKVTVEDIVATAKKYVPEMKAKGADLIIAI
PHSGIGSTENPGDPMAENATYALTYVDGINAILFGHSHSIFPDAKYADLPNTDVTKGLLN
GVPAVMPGRWGDNLGVVDFKLERKDGKWSVLSATTKARPIYDGATKTPLVEADAAIHDAV
AAEHQGTLAFVDEPIGVAAADMYSFLTLVQDDPTVQIVSDAQIANVKAKLPEALKDLPVL
SASAPFKAGGRHGTTSDADQYVQVDKGALTFKNAADLYLYPNTMVAVKATGAELKDWLEC
SVNQFNQIDPTKTTPQELINWDGHPTYNFDVLDGLTYKIDVTQPSKFDRDCAVVNANANR
IVDLSYTDTNGKVFTGEEFAAKEFIVASNNYRAFGGKFAGTGSDHVVLELPDTNREALAA
YITAQSKFNETTGKYEGMVNPSADYNWDFKTISTNVALDIRFQTQDSDKAAAFIEANKQR
EMTKISKDELGFAVYRINLSQDKAK