Protein Info for Shewana3_1517 in Shewanella sp. ANA-3

Annotation: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00218: IGPS
  • amino acids 35 to 280 (246 residues), 294.5 bits, E=5.6e-92
• PF00697: PRAI
  • amino acids 285 to 489 (205 residues), 147.6 bits, E=3.8e-47

Best Hits

Swiss-Prot: 45% identical to TRPC_HELPJ: Tryptophan biosynthesis protein TrpCF (trpC) from Helicobacter pylori (strain J99 / ATCC 700824)

KEGG orthology group: K13498, indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC: 4.1.1.48 5.3.1.24] (inferred from 100% identity to shn:Shewana3_1517)

Predicted SEED Role

"Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Tryptophan synthesis or Auxin biosynthesis (EC 4.1.1.48, EC 5.3.1.24)

MetaCyc Pathways

• superpathway of chorismate metabolism (51/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.48 or 5.3.1.24

Sequence Analysis Tools

See A0KVD2 at UniProt or InterPro

Protein Sequence (493 amino acids)

>Shewana3_1517 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (RefSeq) (Shewanella sp. ANA-3)
MTQVQQPDAHRSEDNQASQDVRGSMQTSTAKANVLTRIVDTKAAHIAALKLRFPEDSLTP
KISDRSLFAALKAPKAGYILECKKASPSKGLIRKDFDVEAIASIYTQYAAGISVLTDEQF
FQGDIDYIPKVRAKVSQPILCKDFFVDEYQVKLAAHQGADAILLMLSVLEDERYQQLASE
AAKYQLDVLTEVSNEEELKRAIALNAPIIGINNRNLRDLSTDLATTEALAPHIGSDRVVI
SESGIYTNEQVRRLSPLVDGFLVGSSIMAEEDIDLACRKLIFGHNKVCGLTRLEDIQAAA
TAGAVYAGLIFAEKSPRALTQEAAKQLVQQYRAANLPAIEFVGVFVNSTPELMASVAQEC
SLAALQLHGSETELEIAELSQLLQQAGLNTQIWKAVSVDAQSGELAAMPRGVQRYLFDSK
NDAGFGGTGQAFNWQLPIAHKAEAMLAGGLNADNAARANAQGFYGLDFNSGLETAPGVKS
AEKIQAAFSQLRL