Protein Info for Shewana3_1096 in Shewanella sp. ANA-3

Annotation: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 381 PF00383: dCMP_cyt_deam_1" amino acids 5 to 103 (99 residues), 76.8 bits, see alignment E=1.6e-25 PF14437: MafB19-deam" amino acids 8 to 109 (102 residues), 48 bits, see alignment E=1.9e-16 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 11 to 368 (358 residues), 394 bits, see alignment E=6.1e-122 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 150 to 371 (222 residues), 172 bits, see alignment E=1.3e-54 PF01872: RibD_C" amino acids 151 to 366 (216 residues), 144.7 bits, see alignment E=5e-46

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 100% identity to shn:Shewana3_1096)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KU62 at UniProt or InterPro

Protein Sequence (381 amino acids)

>Shewana3_1096 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase (RefSeq) (Shewanella sp. ANA-3)
MNWSELDNQMMSRAIQLARKGFYTTRPNPSVGCVIVKDNQIVGEGYHQKAGEPHAEVHAL
RMAGELARGATAYVTLEPCSHYGRTPPCALALINIGVKRVVVAVEDPNPQVGGRGIQMLR
DAGIEVDVGLHRDEAYALNLGFMKRMESGLPWVTVKLAASLDGKTALSNGVSKWITGPEA
RRDVQRLRLRACALVTGIETVLADAPSLNVRYSELGSLNLQLSEAQILQPLRVILDSRCR
MPITAALLAIESPILLVSTEPYSPAFMAQLPAHVTCLQLPAIDGRISLPALLSYLGKSCN
QVLIEAGATLAGAFIGDGLADELVLYQAMKILGAQGRNLLELPDYQMMADIPTLKLVDER
KVGADMRFTLRLTSNPSLANK