Protein Info for Shewana3_1053 in Shewanella sp. ANA-3

Annotation: multi-sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1017 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 375 to 396 (22 residues), see Phobius details amino acids 586 to 605 (20 residues), see Phobius details TIGR02956: TMAO reductase sytem sensor TorS" amino acids 10 to 1012 (1003 residues), 1198.6 bits, see alignment E=0 PF21689: TorS_sensor_domain" amino acids 52 to 220 (169 residues), 50.8 bits, see alignment E=5.2e-17 PF00672: HAMP" amino acids 396 to 441 (46 residues), 23.4 bits, see alignment (E = 1.9e-08) PF00512: HisKA" amino acids 507 to 572 (66 residues), 60.3 bits, see alignment 4.6e-20 PF02518: HATPase_c" amino acids 619 to 729 (111 residues), 80.6 bits, see alignment E=3.5e-26 PF00072: Response_reg" amino acids 750 to 860 (111 residues), 46.3 bits, see alignment E=1.3e-15 PF01627: Hpt" amino acids 924 to 1004 (81 residues), 49.6 bits, see alignment E=1.2e-16

Best Hits

KEGG orthology group: K07647, two-component system, OmpR family, sensor histidine kinase TorS [EC: 2.7.13.3] (inferred from 100% identity to shn:Shewana3_1053)

Predicted SEED Role

"Sensor protein torS (EC 2.7.3.-)" in subsystem trimethylamine N-oxide (TMAO) reductase (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KU19 at UniProt or InterPro

Protein Sequence (1017 amino acids)

>Shewana3_1053 multi-sensor hybrid histidine kinase (RefSeq) (Shewanella sp. ANA-3)
MAPLSLSRSSLTGRLMLAFGVLGVLLLLLVSLGSLSLHWLKQADSYLYEESLPASQAARQ
LVQASNALSDGVTQLGQVEDERQREFIGRKLSLESATMLNSIKVLLTLDVNEDNHLSVLA
GQIIEQLTLLGKSVGQRITLGDELQLRARELSVAAGRASELLQSELAVVDSAILAKLSQA
YPDMAGDKRSGQLLDDVIERELDVQEQLNRVLKLVHQIALLSQLFEASELQSELQLSVPR
LLATFASTAPSHPMAQNHPDHPKQGTAIELATTEAPTAEVGIDLMALTTVAELIRDPGRL
NALKAELAILLHTPKIIKLQRELSQSLQRQQRQQQELAEKLYSLNTLVDSALNQQQQRAE
LARSDYLMQLSYARLGLWGTGILMLVIMAVVVYRVIYRGIALRLNQATEAMSRLSLGDTN
MSLDAHGDDELTAMANAIEAFKRKTAHNLKLQTDLRQVADELTEHKKALEQTVATRTQEL
AEANLRLDAEAKGHAKARIVAEEASQAKSQFLATMSHEIRTPLNGLLGTLTLLGHSQLPP
AQQQMLALSQYSGTLLQTVLSDILDFSRLEQGNLTNEPRPTDINALLDEVLAIMVAGANL
AGLSLRLNCPQLPACIHIDGPKLRQVLFNLIGNGIKFTPEGGVSLNVSVRGDKLAFVVAD
TGVGIAPEVREQLFMPYCVLPNQGRSRGTGLGLAICKQLVELMDAEGPGIWVKSEPGKGS
EFGFELSFTQCDKALDTQTQVQKRVNPQRVLVIEDNKVNAMVAQGFLAHLGHSSSLAVSC
QQALAHVSGDKAFDAVMLDIQLSDGSGLTLLPQLKALFANDNVKFAAFTAQMQTEELSLY
REAGFDTVLAKPLSLQTLTEWLGVARVSASIPASLSESSAHSPQSLQSSNNAEPTSHNHQ
AETLLDLNQLQQDLEVLGVKAVSDMLALYRTSSAEQMERLSALSSVAHFSEGAKLLHSLK
GSSASMGLKALTQCCQQWEKALNTTGENALDSKAVTELTACWQASITAIEQWLATKG