Protein Info for Shewana3_1023 in Shewanella sp. ANA-3

Annotation: membrane protease FtsH catalytic subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 657 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 108 to 129 (22 residues), see Phobius details PF06480: FtsH_ext" amino acids 13 to 100 (88 residues), 66.7 bits, see alignment E=5.5e-22 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 109 to 603 (495 residues), 807.9 bits, see alignment E=1.7e-247 PF07728: AAA_5" amino acids 197 to 318 (122 residues), 25.2 bits, see alignment E=4.3e-09 PF00004: AAA" amino acids 198 to 330 (133 residues), 160.1 bits, see alignment E=1.2e-50 PF17862: AAA_lid_3" amino acids 357 to 396 (40 residues), 44.5 bits, see alignment 2.7e-15 PF01434: Peptidase_M41" amino acids 411 to 601 (191 residues), 239.3 bits, see alignment E=9.6e-75

Best Hits

Swiss-Prot: 79% identical to FTSH_SALTI: ATP-dependent zinc metalloprotease FtsH (ftsH) from Salmonella typhi

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to shn:Shewana3_1023)

MetaCyc: 78% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KTY9 at UniProt or InterPro

Protein Sequence (657 amino acids)

>Shewana3_1023 membrane protease FtsH catalytic subunit (RefSeq) (Shewanella sp. ANA-3)
MRSSNLSDMAKNLILWVVIAVVLMSVFQGYSPSSSSSQKMDYSTFLDNVRDGQVASVEVK
SDQRTIEGSKRTGEKFTTIMPLYDQDLINDLDRKGITMKGQEAEESGFLTQIFISWFPML
LLIGVWIFFMRQMQGGGGKGAMSFGKSKAKLMSEDQIKTTFADVAGCDEAKEEVKELVDY
LRDPTKFQKLGGRIPTGVLMVGPPGTGKTLLAKAIAGESKVPFFTISGSDFVEMFVGVGA
SRVRDMFEQAKKSAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEG
IIVIAATNRPDVLDSALLRPGRFDRQVVVGLPDVRGREQILKVHMRKVPLSEDVKASVIA
RGTPGFSGADLANLVNEAALFAARGNRRVVGMEEFERAKDKIMMGAERRSMVMSEAEKEM
TAYHEAGHAIVGCLVPEHDPVHKVTIIPRGRALGVTFFLPEADAISQSRRKLESQISVAY
GGRLAEELIYGSEKVSTGASQDIKYATSIARNMVTQWGFSEKLGPLLYAEEEGEVFLGRS
MGKAKAMSDETATVIDAEVKAFIDKNYGRAKQILLDNIDILHSMKDALMKYETIDSLQID
DLMNRREVRQPADWQADDNGSNDKGNGKGEPAVKVDEVVKTAPVEAELKDADESPVK