Protein Info for Shewana3_0518 in Shewanella sp. ANA-3

Annotation: CzcA family heavy metal efflux protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1070 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 355 to 372 (18 residues), see Phobius details amino acids 379 to 398 (20 residues), see Phobius details amino acids 405 to 429 (25 residues), see Phobius details amino acids 482 to 502 (21 residues), see Phobius details amino acids 515 to 541 (27 residues), see Phobius details amino acids 572 to 591 (20 residues), see Phobius details amino acids 907 to 926 (20 residues), see Phobius details amino acids 933 to 956 (24 residues), see Phobius details amino acids 963 to 983 (21 residues), see Phobius details amino acids 1005 to 1024 (20 residues), see Phobius details amino acids 1036 to 1059 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1061 (1056 residues), 849 bits, see alignment E=4.9e-259 PF03176: MMPL" amino acids 857 to 1059 (203 residues), 22.4 bits, see alignment E=5.4e-09

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to shn:Shewana3_0518)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KSI9 at UniProt or InterPro

Protein Sequence (1070 amino acids)

>Shewana3_0518 CzcA family heavy metal efflux protein (RefSeq) (Shewanella sp. ANA-3)
MLQKAIEAAIKNRLLVVLALLAVVAASVAMLPKLNLDAFPDVTNVQVTINTAAEGLAAEE
VEKLISYPVESAMYALPAVTEVRSLSRTGLSIVTVVFAEGTDIYFARQQVFEQLQAAREM
IPSGVGVPEIGPNTSGLGQIYQYILRADPSSGINAAELRSLNDYLVKLIMMPVGGVTDVL
SFGGEVRQYQVQVDPNKLRAYGLSMAQVSEALESNNRNAGGWFMDQGQEQLVVRGYGMLP
AGEAGLAAIAQIPLTEVRGTPVRVGDIAQVDFGSEIRVGAVTMTRRDEAGQAQDLGEVVA
GVVLKRMGANTKATIDDIDARINLIEQALPKGVSFEVFYDQADLVDKAVTTVRDALLMAF
VFIVVILALFLVNIRATLLVLLSIPVSIGLALMVMSYYGLSANLMSLGGLAVAIGMLVDG
SVVMVENIFKHLTQPDRRHLAQARSRADGEVDPYHGDEDGSAHAVEADNNMAVRIMLAAK
EVCSPIFFATAIIIVVFAPLFALEGVEGKLFQPMAVSIILAMISALLVALIAVPALAVYL
FKRGVVLKESVVLAPLDSAYRKLLSATLARPKLVMTSALLMFAMSMVLLPRLGTEFVPEL
EEGTINLRVTLAPTASLGTSLDVAPKLEAMLLEFPEVEYALSRIGAPELGGDPEPVSNIE
VYIGLKPIEEWQSASSRLELQRLMEEKLSVFPGLLLTFSQPIATRVDELLSGVKAQLAIK
LFGPDLDVLSEKGQVLTDLVAKIPGAVDVSLEQVSGEAQLVVRPDRAQLARYGISVDQVM
SLVSQGIGGASAGQVIDGNARYDINLRLAAQYRSSPDVIKDLLLSGSNGATVRLGEVASV
EVEMAPPNIRRDDVQRRVVVQANVAGRDMGSVVKDIYALVPQADLPAGYTVIVGGQYENQ
QRAQQKLMLVVPISIALIALLLYFSFGAVKQVLLIMANVPLALIGGIVALFVSGTYLSVP
SSIGFITLFGVAVLNGVVLVDSINQRRQSGESLYDSVYEGTVGRLRPVLMTALTSALGLI
PILVSSGVGSEIQKPLAVVIIGGLFSSTALTLLVLPTLYRWLYRHDKSSA