Protein Info for Shewana3_0480 in Shewanella sp. ANA-3

Annotation: putative PAS/PAC sensor protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1686 transmembrane" amino acids 35 to 56 (22 residues), see Phobius details amino acids 665 to 684 (20 residues), see Phobius details PF00532: Peripla_BP_1" amino acids 94 to 294 (201 residues), 24.2 bits, see alignment E=1.2e-08 PF13407: Peripla_BP_4" amino acids 95 to 347 (253 residues), 64.8 bits, see alignment E=5e-21 PF00497: SBP_bac_3" amino acids 435 to 652 (218 residues), 63.1 bits, see alignment E=1.3e-20 TIGR00229: PAS domain S-box protein" amino acids 706 to 829 (124 residues), 36.1 bits, see alignment 3.1e-13 PF13188: PAS_8" amino acids 708 to 763 (56 residues), 26.7 bits, see alignment (E = 2.1e-09) amino acids 839 to 889 (51 residues), 14.8 bits, see alignment (E = 1.2e-05) PF00989: PAS" amino acids 709 to 821 (113 residues), 26.5 bits, see alignment 3.1e-09 PF08448: PAS_4" amino acids 714 to 826 (113 residues), 32.6 bits, see alignment 4.4e-11 PF13426: PAS_9" amino acids 719 to 824 (106 residues), 23.4 bits, see alignment 3.4e-08 amino acids 849 to 941 (93 residues), 18.2 bits, see alignment 1.3e-06 PF00512: HisKA" amino acids 962 to 1027 (66 residues), 66.1 bits, see alignment (E = 1.3e-21) PF02518: HATPase_c" amino acids 1074 to 1188 (115 residues), 88.2 bits, see alignment 2.8e-28 PF00072: Response_reg" amino acids 1346 to 1455 (110 residues), 95.6 bits, see alignment 1.2e-30 PF01627: Hpt" amino acids 1506 to 1586 (81 residues), 44.3 bits, see alignment 9.6e-15

Best Hits

KEGG orthology group: None (inferred from 100% identity to shn:Shewana3_0480)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KSF2 at UniProt or InterPro

Protein Sequence (1686 amino acids)

>Shewana3_0480 putative PAS/PAC sensor protein (RefSeq) (Shewanella sp. ANA-3)
MAVFGILSGRLDKAIRHIFTTIGGQRQSVKPSVRVISSLGYFACLLSLSASLLWLWPNTI
AANEMSLQEHRQALSQLTPAQKLAHSHRVSMILEADRPFWNQVAKFAKIAAMDLNIQLDI
VYGDGTPETLLALGHEAIDNAVAGIIFVPILGMGQDLLVEAKRNNIPVVTINSEFAQSSL
ALRTQNPNWVGKVTMNSSNLGQNLLEKMFEEEASSEQMNLLLLAGSKDNLDVQKRTAELK
NAVSRQFANAKFKVVNTDWSASAARAAYLKAIQQDPNINTVIAMNTTMAMAVTHEAEADT
SRPMPHIGSLSWNHQLAQGIQKGTVAAGVGGVEFQGAFGLVLLFDYLNGVDTRAKGFEFQ
VLPLIISPNNYNDYYELLDFDSLQPDFSRVSLALNTNLFLVDFRLGSLIPNMDVHRFMTQ
LSVEERAFINNNPIVKVGIDPHSAPIDFIDENGIHRGMMADYLAEISRVVPLIFQTYNEG
SWQQAIDEFKRHDVDMLSLASANAGREQWMLFTDAINQYPPVIVTHVDGEHPSSLEQLKG
KSVSVVSGDVTQTQLLEDYPEIVLIPFENLEQALMAVKQHQVDAAFVNFPSTAYLLQSPQ
FNRLQIVSASDYRFGISMGVRKDWPELQSILNKALAQIPQDKVREIQHRWVNVQYELGLK
KQQVFDWAVRIAVAVVLVLLMFSLRNRRLNKDIAQRIHTEEQLSLSMNKFQALFDSAVDA
CVITDRQGVIIECNSALLSLLKYQHKHQLIGRRTLVYYPPHLGETDSETLFEQRLQTVLE
QGQLRFEADFVTSMAEIVNVEVTLKRIELNGSLFVLGTYHDLSERKLMNALLERERDLLK
HVLGRSPIGVWICIEGVCRYVNEQITEMTGLQVGQSVYPIFAQPDDYRCHISELDLSQDS
TVFETQLFDCKGQRRDVLLTAYHTVQDGQNANLCWALDITDTKSIQDELAIAKDAAEAAN
RAKSDFLANMSHEIRTPMNAILGMSYLVLQTELSSKQRDYVGKVHQAAGSLLGILNDILD
FSKIEAEKMDIECAVFDLDDVLSNLANVVSYKVEEKNMAFIFDLPPELPRYYHGDGLRLG
QILINYCNNAVKFSHNDSNVVLSCESKVHGEQVELTFCVEDFGIGIPEQKQGVLFGSFEQ
VDASTSREYGGTGLGLAICKRLAHLMGGEVWCESELGVGSRFYVRLTLDCADTYDPNALF
DPLAGETAKLIGLHPRLDKLLTIHGVSANMQVESADVGTVIAQLKQSSTRQLLICDYSAF
VPELLEALAVNQASRMLLIGQLSDQDSLRQLIENNDRVISQTKPLTPIAIGNALLSLLGH
QSEDGRQVQQDHSLHALKTQLAGAEVLLVEDNQLNQELAVELLRQAGINVTVANHGLEAI
ERVEQQYFDCVLMDCQMPVLDGYEATRRIRELPQFANLPILAMTANAMSGDIEKALAVGM
NDQITKPVHVKDLYTVMARWITPKQRKSVPLVLKRSTHAQDLPQLEGLSIQNGLSHCDHN
ESLYSHLLGLFINTSKTLLGQQQRAWQEENADELRLSLHTLKGVAANVGAMEISRLASEL
ELQCLTAKRSFTVELHEQLLALQTELQCLVSGLEIWYQQNNSIKPEASFSDEALAAMWPQ
LEQSLLEYNTNALEWVNKLTHAPQLQGESGLLKQLKMDVELFDFEQALVRLLTLKQAQQA
RATTCS