Protein Info for Shewana3_0383 in Shewanella sp. ANA-3

Annotation: HemY domain-containing protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 388 signal peptide" amino acids 5 to 5 (1 residues), see Phobius details transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 42 to 70 (29 residues), see Phobius details TIGR00540: heme biosynthesis-associated TPR protein" amino acids 5 to 385 (381 residues), 240.7 bits, see alignment E=1.1e-75 PF07219: HemY_N" amino acids 26 to 131 (106 residues), 94.1 bits, see alignment E=2.8e-31

Best Hits

KEGG orthology group: K02498, HemY protein (inferred from 100% identity to shn:Shewana3_0383)

Predicted SEED Role

"Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KS57 at UniProt or InterPro

Protein Sequence (388 amino acids)

>Shewana3_0383 HemY domain-containing protein (RefSeq) (Shewanella sp. ANA-3)
MIKALIFLGIILIGLCISPWIVGNTGYVYIAAGDYQLETSLVFGIIMLIVFYALFQVLEW
LVITVINLLLRSRFIPQHWRRRSAKKHTLIGALAIAEEDWPAAERAMIKGADNGELPALN
LLAAARAAQHQNKIAERDQYLARAEAQPMTANAVATTRTRYLLKQGELALARAELDKLAP
TSKSKAPVLKLALELYRAQEDWEALKLLLPILKKRQILEDAKLNALSVETHCALLKAASL
KGEDALEQCWQWLSRDERNQSEFLAIYAMGLCRFNRKDQALKLLSKKLRSSPESALLEVI
PQIVTAHDEEIRKQLLKHEITHENNADYQKCLALLYQQTRDMKEAKTCWQNVCRLAPSQA
SWLSLARIQEQLGEQGNANQSYRQAVNL