Protein Info for Shewana3_0268 in Shewanella sp. ANA-3

Annotation: site-specific DNA-methyltransferase (adenine-specific) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 279 PF00294: PfkB" amino acids 3 to 118 (116 residues), 43.4 bits, see alignment E=1.4e-15 amino acids 195 to 267 (73 residues), 63 bits, see alignment E=1.6e-21

Best Hits

KEGG orthology group: K00571, site-specific DNA-methyltransferase (adenine-specific) [EC: 2.1.1.72] (inferred from 100% identity to shn:Shewana3_0268)

Predicted SEED Role

"Carbohydrate kinase, PfkB family"

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KRU2 at UniProt or InterPro

Protein Sequence (279 amino acids)

>Shewana3_0268 site-specific DNA-methyltransferase (adenine-specific) (RefSeq) (Shewanella sp. ANA-3)
MANILLVANLNCDRVLILDKPLKTGGRFHYQDGGQRLGGGGANTGLGLVWAGHRVALVSQ
VGRDEMGDWVIAEASTQGLDCRLVQRRAGNTCEMLLVMTPDGERTIIRPQRPIFELSVPP
KWQHWDALYFNTSAEGTVSWAKTALDHCLVIAQLAKDDRPRPCHVLLASVSDMQGRCDVA
SWDYGVSIGGESLRYFVVTDGVRGAKVYTRDDVQHVPAVPAEVVDTTGAGDAYAAGLIHG
LCAGKTITQAMAEGATWAAFAVATDSSIPGDALKQYLEA