Protein Info for Shewana3_0098 in Shewanella sp. ANA-3

Annotation: imidazolonepropionase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 TIGR01224: imidazolonepropionase" amino acids 27 to 404 (378 residues), 494.2 bits, see alignment E=1.1e-152 PF01979: Amidohydro_1" amino acids 64 to 406 (343 residues), 76.4 bits, see alignment E=2.5e-25 PF07969: Amidohydro_3" amino acids 114 to 407 (294 residues), 57 bits, see alignment E=2.6e-19

Best Hits

Swiss-Prot: 100% identical to HUTI_SHESA: Imidazolonepropionase (hutI) from Shewanella sp. (strain ANA-3)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 100% identity to shm:Shewmr7_0092)

MetaCyc: 59% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0KRC4 at UniProt or InterPro

Protein Sequence (408 amino acids)

>Shewana3_0098 imidazolonepropionase (RefSeq) (Shewanella sp. ANA-3)
MSWDQVWIDVNVATMDPSISAPYGAITNAAIAVKDGKIAWLGPRSELPAFDVLSIPVYRG
KGGWITPGLIDAHTHLVFAGNRANEFELRLKGATYEEIARAGGGIISTVNACREADEAEL
FDLGRQRLNALAKEGVTTVEIKSGYGLDTETELKILRVARELGQHHHVDVKTTFLGAHAV
PPEFKDNSDGYVDLIINKMLPAVIAENLADAVDVFCENIAFNLEQTERVLSAAKAAGLQV
KLHAEQLSNMGGSELAARLGAKSVDHIEYLDEAGVKALSESGTCAVLLPGAFYFLRETQK
PPIDLLRQYGVPMVLASDFNPGSSPICSTLLMLNMGCTLFRLTPEEALAGLTLNAAKALG
IEESVGSLVVGKQADFCLWDIATPAQLAYSYGVNPCKDVVKNGKLVHQ