Protein Info for Shewana3_4384 in Shewanella sp. ANA-3

Annotation: CzcA family heavy metal efflux protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1047 transmembrane" amino acids 14 to 31 (18 residues), see Phobius details amino acids 344 to 362 (19 residues), see Phobius details amino acids 369 to 387 (19 residues), see Phobius details amino acids 394 to 414 (21 residues), see Phobius details amino acids 446 to 466 (21 residues), see Phobius details amino acids 478 to 504 (27 residues), see Phobius details amino acids 533 to 552 (20 residues), see Phobius details amino acids 872 to 891 (20 residues), see Phobius details amino acids 898 to 917 (20 residues), see Phobius details amino acids 923 to 948 (26 residues), see Phobius details amino acids 969 to 989 (21 residues), see Phobius details amino acids 1001 to 1024 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1034 (1034 residues), 1434.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1028 (1024 residues), 1021 bits, see alignment E=0

Best Hits

Swiss-Prot: 57% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 74% identity to amc:MADE_00305)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L3G6 at UniProt or InterPro

Protein Sequence (1047 amino acids)

>Shewana3_4384 CzcA family heavy metal efflux protein (RefSeq) (Shewanella sp. ANA-3)
MLESILRFSIKRKFLVLVMVIAVAGLGLWNFTKLPIDAVPDITNVQVMINTEAPGYTPLE
IEQRVTFPLETALAGLPGLTYTRSVSRYGLSQVVAIFSDETDVYFARQLVNERLSAARSE
LPLGLEPQLGPIATGLGEIFMFTVDALPDATHADGTPITPMDLRTVHDWTIRPQLMRVPG
VVEVNPIGGFEREILVAFKPEKLLAFGLTQADVVDAIAKNNQNQGAGFIEQNGAQWLLRM
PGQAEDIVAIGNIPLKSTQGSALTIKDVADIENGQGLRNGAATQNGREVVMSTVFMLIGE
NSRTVAHAVGEKLKEINATLPEGIVATAVYDRTKLVDKTLQTVQTNLLEGALLVIVVLFV
LLGNFRAAFLTALVIPFAMLMTITGMVQTRVSANLMSLGALDFGLLVDGAIIIVENCLRR
LSQAGDDPLPLKERLELVFEATREVIRPALFGVFIITAVYLPIFALEGVEGKMFHPMAIT
VVIALLSAMLLSVTFVPATIALLFKKPVKEKHSPLIRGAGALYRPALNRVIQGRWVVVIA
ATLLVAVFGYQATKLGSEFAPNLDEGDIAMHALRIPGTSLSQAIALQETLEDKIKQMPEV
ERVFAKIGTADVATDAVPPSVADNFIILKPREQWPNPNKSKEQIVEELAAMVEPIPGNRY
EFLQPIQMRFNELLAGVRAELAIKVFGDDFDTLTSLGAQIEAAIAQVDGIADVQVEQTTG
LPMLNIIPKRQQLMQHGLSMAELQSQVATAMGGTVASKFYEGDIRSDIVVRLGESRRQNL
DGLRYLPISLPDRHSIPLQELASLELVSGANQINRENGKRRMVVTANVRGRDLGSFVADI
QNVIGERVDIPAGYSVEYGGTYQKLQSASHRLSIVVPVTLLMIVGLLILALSSFKDAMII
FTGVPLALTGGIAALLLRDIPFSISAAVGFIALSGIAILNGLVMVSFIRELRKEGMGLDR
AIFEGALTRLRPVLTTALVASLGFIPMALNTGIGSEVQRPLATVVIGGIISSTLLTLFVI
PALYRILHKEKESILTEVEVMEIADAK