Protein Info for Shewana3_4244 in Shewanella sp. ANA-3

Annotation: HsdR family type I site-specific deoxyribonuclease (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1084 PF04313: HSDR_N" amino acids 2 to 213 (212 residues), 168.6 bits, see alignment E=3.9e-53 PF18766: SWI2_SNF2" amino acids 271 to 550 (280 residues), 253.6 bits, see alignment E=4.2e-79 PF04851: ResIII" amino acids 301 to 487 (187 residues), 61.4 bits, see alignment E=2.6e-20 TIGR00348: type I site-specific deoxyribonuclease, HsdR family" amino acids 315 to 742 (428 residues), 447.8 bits, see alignment E=3.7e-138 PF22679: T1R_D3-like" amino acids 657 to 723 (67 residues), 73.9 bits, see alignment 5.1e-24 PF11867: T1RH-like_C" amino acids 740 to 1080 (341 residues), 391.5 bits, see alignment E=9.4e-121

Best Hits

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L328 at UniProt or InterPro

Protein Sequence (1084 amino acids)

>Shewana3_4244 HsdR family type I site-specific deoxyribonuclease (RefSeq) (Shewanella sp. ANA-3)
MITEDQLEQLCLDWFTDQGYLYKNGYDIAPDGDSPERDDYHQVVLKQRLLERLEVLNPEL
PQESLDVVVNTVSTPDTPVLIKSNRGFHKYLIEGVPVEYTVYEDGETKTKHTHARLMDFT
NPDNNEFLVVNQFTITGKKGNRRPDVVVFINGLPIAVIELKNPADEHADIWHAYNQLQTY
KDEIPDLFVFNESLVVSDGWTARVGSLTANKERFLPWKTVSGEDDKPLWDYQLETMVKGF
FKPDLLLDYIRYFVLFETDNDTVIKKIAGYHQFHAVRAAVEATVRAKQADGELPLVAESM
GQYQVQATKGLDKIKPGSGKAGVVWHTQGSGKSISMVCYASKLLQQPAMNNPTIVVVTDR
NDLDGQLFNTFGMAHETLKQVPSQADGRDKLRELLLSRQSGGIIFTTIQKFALLAEETEH
PVLSTRANIVVVSDEAHRSQYGNKSKLVDVKDANGNVISQKFVYGYSKYMRDALPNASFI
GFTGTPIAMDDKDTRGVFGEYVSIYDIQDAVDDGATVPIYYESRLAKLDINQAEIEQLND
QIEDEIGEDEETASREKIKSQWATLEKLVGAEPRIQQVAQDLVNHFTTRTETFPGKAMIV
AMSREICVDLYNAIVAIKPEWHNDDPAKGAIKIVMTGSASDKPKMQPHIHDKKTKKLFEA
RYKDTQDELQLVIVRDMWLTGFDAPCCHTMYVDKPMKGHNLMQAIARVNRVFKDKPGGLV
VDYIGIANELKNALKTYTNSQGKGQPTVDTAEAFSVLMEKVDIVRGMFATPVDGKVFNYR
PDFETDALRLLPGAVNHLSGLSHTDSKGKEVRDGKRRFLDVMAALGKAYSLCNTMDETRG
YKNEIAFYSAIKAAFMKHSTVDKKRTDEERNTALKQILDNAVIADGVDDIFSMVGLDKPN
IGLLSEEFLEDVKNMKEKNLAVELLEKLLRDEVKARMKNDVVQEKKYSDRILTTLNKYHN
RSIETAQVIEELIQWAKEMQEDAEMVDKLNLSVDEMAFYRALVENESSVRELGNDDLRNL
AIELTQQLRKSATVDWQKRESVRARMRNLVRRLLRRWKYPPDSAEEAIKLVLEQAEVLAD
GWYK