Protein Info for Shewana3_4204 in Shewanella sp. ANA-3

Annotation: UvrD/REP helicase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 599 PF00580: UvrD-helicase" amino acids 14 to 249 (236 residues), 117.7 bits, see alignment E=1.9e-37 PF13245: AAA_19" amino acids 15 to 234 (220 residues), 67.5 bits, see alignment E=3.4e-22 PF13361: UvrD_C" amino acids 254 to 387 (134 residues), 29.3 bits, see alignment E=1.6e-10 amino acids 484 to 568 (85 residues), 78.2 bits, see alignment E=2e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to shn:Shewana3_4204)

Predicted SEED Role

"Plasmid conjugative transfer DNA helicase TrhI" in subsystem DNA repair, bacterial UvrD and related helicases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0L2Y9 at UniProt or InterPro

Protein Sequence (599 amino acids)

>Shewana3_4204 UvrD/REP helicase (RefSeq) (Shewanella sp. ANA-3)
MGSTKDQGLVIERDDNTLVCALPGSGKTYVLVELTKRLLSRDGAYSVHLLTFTDAARVEL
TERMLHALTPRAMERVTISTFHSTALAMTRGKLNRRLLMANELMLFVKSVLNEADHLDLI
DKFRFKVPDVVRLFDEMGRSQDLSKEYSGTEVALYELYKDMLIKQGKTDFNVVCQLSVSW
LAQREIPPVSATHILVDEFQDTDALQYMWLREHALLGKKLVVVGDDDQAIYSFRGGQGYD
NMVAFQSEFNADAYVLRDCFRCSKEILNRAGMLIKFNNPDRIDKPMNAVREEQGTVKIIK
SGTMDNQLNQILDAVSKEPHTWAVIARNNAILDRVETVIQGHGIEYNRRGGKSFFDGVAP
YSLIQIASVISGKHDDHTLHRALAALSVPEAETARIIGLCRTAKTTFGGLKHAEIGHHAD
LQKFHSLAEAWHDIPAGREDAKRTYMQSIVKLLAIHLDKRDQKHAQVVGDVIAGRHWESL
GESIAQLKSSLDCKKRKDQSEEAAPKLSLITMHSSKGLQFDNVWIVGSDTGTIPSKEALA
EGKIAEERRLMYVAMTRAISSLTMSYTSEPSEFLYEVNKERVVELESGYEDDADDFDAA