Protein Info for Sama_3433 in Shewanella amazonensis SB2B

Annotation: sensor protein CpxA (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 453 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details PF16527: CpxA_peri" amino acids 46 to 157 (112 residues), 29.8 bits, see alignment E=1.4e-10 PF00672: HAMP" amino acids 180 to 235 (56 residues), 52.9 bits, see alignment 7.6e-18 PF00512: HisKA" amino acids 240 to 299 (60 residues), 48.7 bits, see alignment E=1.3e-16 PF02518: HATPase_c" amino acids 347 to 452 (106 residues), 78.5 bits, see alignment E=1e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to saz:Sama_3433)

Predicted SEED Role

"Copper sensory histidine kinase CpxA" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1SB79 at UniProt or InterPro

Protein Sequence (453 amino acids)

>Sama_3433 sensor protein CpxA (RefSeq) (Shewanella amazonensis SB2B)
MNTQTLPNRLFIKLLLGFWLCSSVVLVAVGSLPLLQQQRESTPIPKELQQTLDKIARAIE
REPELMEPERMRRWERSRHADGKPMRVFITNEEGRILGERQPRSLRKFILLAEEAERPIM
YQFRDEMVFGPKEFHVDGKEYHLYGRVPGQHPRPLFLFFIEHKLLTLGLAVLVSGLLCGL
LAWHLGRPLKMLKQSADALARGNLGSRVDEATLNRRDELGQLGHAFNAMAEAIEQQVNNQ
QRLMGDISHELRTPLTRLQLALALARKRGQDSNELNRIAHEAEQLDALIAELLTLSRVTM
GATEAKVDIELAETLGQVLDDAEFEASECGKHLAIEMDDNLLLSHTPKLLARAVENLLRN
AIRYARLQVSLTVTDTQDRIEIQICDDGPGVADAELEAIFRPFYRTDKSRERESGGWGLG
LAITAAAIEAQGGSISAQNRPTGGLCVTICLPR