Protein Info for Sama_3304 in Shewanella amazonensis SB2B

Annotation: sensor histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 34 to 57 (24 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details PF02518: HATPase_c" amino acids 361 to 465 (105 residues), 65 bits, see alignment E=8.2e-22 PF14501: HATPase_c_5" amino acids 364 to 447 (84 residues), 28.4 bits, see alignment E=1.3e-10

Best Hits

KEGG orthology group: K07637, two-component system, OmpR family, sensor histidine kinase PhoQ [EC: 2.7.13.3] (inferred from 100% identity to saz:Sama_3304)

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1SAV0 at UniProt or InterPro

Protein Sequence (466 amino acids)

>Sama_3304 sensor histidine kinase (RefSeq) (Shewanella amazonensis SB2B)
MSHSASTPKPVPAAAPAHKQAAAFIDRLSLKTRLFVSAAILVALLLPALGIALFQAFERQ
ALAGSRDELGALIYSVLAQTDVIDGKLEMPPFLNEPQFNVDGSGLYAEVRSGAGEVLWRS
GSLIGHGAIPALPSPAPGADAKVFGETLLNDEPLFVMSFTAVYESKGVDVPLSIHILKSQ
QRYREALTEFESSLWRYLLLALALLAVVLGLWLRWTLKPLSRFEAELKAVEHGDKERIDT
DYPTELGPLVHQLNSLLTTEQNQRKRYRNALSDLAHSLKTPLAVLQSHPGLDDAVMEQVD
NISHSISHQLKRAQSAGAASWHQGVEILPQAERLTRTLSKIHGDKGIDFELKLAAELVFK
GDKGDLTELLGNLLDNACKAARSRVCLSAAKQDGRLRLIVEDDGPGVDESMRDKIFERGI
RADTYDKGHGIGLAIVQDLTDAYQGRLLLGRSDLLGGARFEVSFPQ