Protein Info for Sama_3188 in Shewanella amazonensis SB2B

Annotation: CzcA family heavy metal efflux protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1066 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 355 to 372 (18 residues), see Phobius details amino acids 379 to 398 (20 residues), see Phobius details amino acids 404 to 425 (22 residues), see Phobius details amino acids 474 to 494 (21 residues), see Phobius details amino acids 507 to 533 (27 residues), see Phobius details amino acids 563 to 582 (20 residues), see Phobius details amino acids 899 to 918 (20 residues), see Phobius details amino acids 925 to 946 (22 residues), see Phobius details amino acids 954 to 974 (21 residues), see Phobius details amino acids 997 to 1016 (20 residues), see Phobius details amino acids 1028 to 1053 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1061 (1061 residues), 970.9 bits, see alignment E=3.8e-296 PF00873: ACR_tran" amino acids 6 to 1054 (1049 residues), 845.9 bits, see alignment E=4.1e-258

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to saz:Sama_3188)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1SAI4 at UniProt or InterPro

Protein Sequence (1066 amino acids)

>Sama_3188 CzcA family heavy metal efflux protein (RefSeq) (Shewanella amazonensis SB2B)
MLQKLIEQAVRSRLIVLIFLIGAMAAAAVMLPKLNLDAFPDVTNVQVQVNTAAEGLAAEE
VEKLISYPVESAMYALPSVTEVRSLSRTGLSIVTVVFEEGTDIYFARQQVFEQLQAAREA
IPDGVGVPEIGPNTSGLGQVYQYILRAAPESGIAPDELRSLNDYLVKLIMMPVGGVTDVL
SFGGEVRQYQVQVDPAKLLSYGLKLDDVTRALEGNNRNAGGWFMAKGQEQLVVRGYGLLP
AGEAGLDAIAQIPLTEWQGTPVRIMDVAQVAFGSEIRVGAVTMTRRDEAGSPQVLGEVVA
GVILKRMGANTKATIDDINSRTALIQQALPDGVTFEVFYDQSDLVTKAVTTVRDALLLAF
MFIVAVLALFLVNVRATALVLLSIPVSIALALMVMSYFGMSANLMSLGGLAVAIGMLVDG
SVVMVENIFRHLTQPEGRVDNGLPTDPGLSEEDAHREGGYGGIAMRILQAAREVCSPIFF
ATLIIIVVFAPLFALEGVEGKLFQPMAVSIILAMLSALMVALVVVPALAVYLFRRGVHLR
QSPLLTPIDKGYRRVLGAVMARPKTVGITALVLFGLSMALLPRLGTEFVPELEEGTINLR
VTLAPTASLDTSLMVAPKLEAMLMEFPEVDYALSRIGAPELGGDPEPVSNIEIYIGLKPI
DEWQSAASRAELQRLMEEKLSVFPGLLFTFSQPIATRVDELLSGVKAQLAIKLFGPDLDV
LAEKGQQLSELVSKVPGAVDVSLEQVSGEAQLVVRPDRARLARYGISVDEVMNLVSTGIG
GSDAGQVIDGNARYDINVRLKADTRASADAIADLLLVGANGARVRLGEVADVVVEMAPPN
IRRDDVQRRVVVQANVSGRDMGSVVKDIYALVPEADLPPGYTVSVGGQYENQQRAQARLM
LVVPVSIGLIALLLYFSFGALKQVGLIMANVPLALIGGVVALYVSGTYLSVPSSIGFITL
FGVAVLNGVVLVDSINQRRAGGEGLYQAVYEGTAARLRPVLMTALTSALGLIPILLSSGV
GSEIQQPLAVVIIGGLFSSTALTLLVLPTLYMALYRQNDRELEEPG