Protein Info for Sama_2637 in Shewanella amazonensis SB2B

Annotation: succinate-semialdehyde dehydrogenase (NAD(P)(+)) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 73% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to saz:Sama_2637)

MetaCyc: 72% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

4-aminobutanoate degradation III (2/2 steps found)
methylglyoxal degradation V (2/3 steps found)
L-lactaldehyde degradation (aerobic) (1/2 steps found)
methylglyoxal degradation IV (1/3 steps found)
lactate biosynthesis (archaea) (2/5 steps found)
superpathway of methylglyoxal degradation (3/8 steps found)
L-rhamnose degradation II (2/8 steps found)
superpathway of fucose and rhamnose degradation (3/12 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A1S8Y3 at UniProt or InterPro

Protein Sequence (480 amino acids)

>Sama_2637 succinate-semialdehyde dehydrogenase (NAD(P)(+)) (RefSeq) (Shewanella amazonensis SB2B)
MQLKRPSLLKTKCYINGEWRDALSGETVTIANPATNEAIASVPVMGRDETREAIAAAEAA
LPAWRALTAKERGAKLRRWYELMLENADDLALMMTTEQGKPLAEAKGEVVYAASFIEWFA
EEAKRLYGDTIPGHQGDKRIMVIKQGVGVTAAITPWNFPAAMITRKAGPALAAGCTMIVK
PAPQTPFTALALAELAAEAGIPPGVFSVVTGDAVAIGNELCENPVVRKLSFTGSTGVGIK
LMQQCAPTLKKVSLELGGNAPFIVFNDADLDAAVEGAMISKYRNAGQTCVCANRLYVQDG
VYDAFAQKLAAAVAKLKVGNGAEPGVTTGPLINAAALEKVQSHLQDALDKGATLVAGGKP
LGGNFMEPAIVTNVDASMKVAREETFGPLAPLFRFSDVDDVIRQANDTEFGLAAYFYGRD
ISLIWKVAEALEYGMVGVNTGLISTEVAPFGGMKSSGLGREGSKYGIDEYVEIKYICLSV