Protein Info for Sama_2515 in Shewanella amazonensis SB2B

Name: proA
Annotation: gamma-glutamyl phosphate reductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 14 to 410 (397 residues), 531 bits, E=8.4e-164
• PF00171: Aldedh
  • amino acids 20 to 272 (253 residues), 46.4 bits, E=1.1e-16

Best Hits

Swiss-Prot: 100% identical to PROA_SHEAM: Gamma-glutamyl phosphate reductase (proA) from Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 100% identity to saz:Sama_2515)

MetaCyc: 59% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-citrulline biosynthesis (7/8 steps found)
• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• L-N^δ-acetylornithine biosynthesis (5/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Sequence Analysis Tools

See A1S8L1 at UniProt or InterPro

Protein Sequence (420 amino acids)

>Sama_2515 gamma-glutamyl phosphate reductase (RefSeq) (Shewanella amazonensis SB2B)
MDAQAYLLQLGQAAKSSGFALANLGVMAKNRLLGRVAAELKSAFDEILAANAKDVAAARA
SGLGDAMVDRLLLNDDRLKGIIADIDNVISLADPIGEEFDSRLLDNGMRLCRRRVPLGVI
GVIYEARPNVTVEIAVLALKTGNAVILRGGKETLESNLALAAAIRRALAGEGLPEDCVQL
IDNPDRALVTGLLKLDKFVDMIVPRGGQGLQRLCAEQATIPVILGGIGICHLYLDRDADI
SRAANVIINAKVQRPTVCNALDTLLIHRDKLDWLPTLARALQQQGVKLVACEQSLGALAA
AGIEAEAASDESFGTEWLSLTLGVKVVADIDEAIAHIRHYSSGHSEAILTDNLAAATHFM
NEVNSAAVYLNASTRFTDGGQFGFGAEVAVSTQKLHARGPMGLEALTTYKWLGVGDYSCR